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| Sim | Doc | Source | Pred | Domain | Prior | |
|---|---|---|---|---|---|---|
| 0.59 | FDA NDA220837: EVDI (TRABECTEDIN) — APOTEX | fda 2026-05-01 | COD_BIO_002 An AI-designed Isomorphic or peer drug enters or completes Phase 1 by end 2027 Codex Research Pack | Biotech/Longevity | 50% | |
| 0.59 | FDA ANDA211182: ANDA211182 ((unspecified)) — HETERO LABS LTD V | fda 2026-04-16 | 248_030 FDA will be first government agency forced to get out of the way; government must accelerate regulation speed thousands of times. Dave Blundin | Geopolitics | 50% | |
| 0.59 | FDA ANDA090348: ZIPRASIDONE HYDROCHLORIDE (ZIPRASIDONE HYDROCHLORIDE) — CHARTWELL RX | fda 2026-04-24 | COD_BIO_001 FDA finalizes or materially advances AI-for-drug-submission guidance by end 2026 Codex Research Pack | Biotech/Longevity | 47% | |
| 0.59 | FDA NDA217180: JAKAFI XR (RUXOLITINIB PHOSPHATE) — INCYTE CORPORATION | fda 2026-05-01 | INF_027 AI infrastructure applied to structural biology will compress drug-development timelines from approximately a decade to weeks — potentially eradicating many major diseases within 10 years. Requires localized high-speed InfiniBand networking inside the DC. Demis Hassabis | Biotech/Longevity | 38% | |
| 0.59 | FDA ANDA208103: DEXMEDETOMIDINE HYDROCHLORIDE (DEXMEDETOMIDINE HYDROCHLORIDE) — BAXTER HLTHCARE CORP | fda 2026-04-15 | COD_BIO_001 FDA finalizes or materially advances AI-for-drug-submission guidance by end 2026 Codex Research Pack | Biotech/Longevity | 47% | |
| 0.59 | Spread: Thunder (-15.5)(market prob: 49%) | polymarket 2026-05-06 | 246_023 Grok 5 release ~20% probability for Q2 2026 per PolyMarket. PolyMarket | AI | 43% | |
| 0.59 | Will FC Barcelona win on 2026-05-10?(market prob: 60%) | polymarket 2026-04-27 | 246_023 Grok 5 release ~20% probability for Q2 2026 per PolyMarket. PolyMarket | AI | 43% | |
| 0.59 | polymarket 2026-05-07 | FUT_024 XPT 2022 tournament assigned mere 2.3% probability to AI achieving gold-medal performance in International Mathematical Olympiad by 2025 — actual achievement empirically reached forcing systemic re-evaluation within forecasting community. Historical tr... Superforecaster Community | AI | 100% | ||
| 0.59 | Spread: Thunder (-14.5)(market prob: 52%) | polymarket 2026-05-07 | 246_023 Grok 5 release ~20% probability for Q2 2026 per PolyMarket. PolyMarket | AI | 43% | |
| 0.59 | Will Finland be in the top 10 at Eurovision 2026?(market prob: 97%) | polymarket 2026-02-17 | 241_011 By end of 2026, no one will write code manually - it'll be a quaint skill Peter Diamandis | Labor/Jobs | 47% | |
| 0.59 | Will Democrats have 225 or more seats after the 2026 House Elections?(market prob: 65%) | manifold 2026-05-07 | 235_005 AI capability will grow 100x this year in raw parameter count as lower bound. Dave Blundin | AI | 49% | |
| 0.59 | arxiv 2026-05-06 | AI_010 The 2026 development landscape has entered the 'Slopacolypse' — AI writes the vast majority of new code, developer manual-coding skills atrophy, and engineering transitions from syntax-writing to high-level architectural prompting and 'vibe coding'. Andrej Karpathy | AI | 90% | ||
| 0.59 | arxiv 2026-05-06 | ROB_013 Research foundations enabling seamless human-robot interaction in complex 3D physical spaces — algorithms translating human natural-language intent directly into complex robotic actuation eliminate hard-coded robotics engineering, allowing systems to g... Jimmy Ba | Robotics | 62% | ||
| 0.59 | arxiv 2026-05-06 | TK01 AGI Capability Plateau (2026-27 Training Stall) | — | 15% | ||
| 0.59 | FDA BLA761328: BEYFORTUS (NIRSEVIMAB-ALIP) — ASTRAZENECA AB | fda 2026-04-07 | COD_BIO_002 An AI-designed Isomorphic or peer drug enters or completes Phase 1 by end 2027 Codex Research Pack | Biotech/Longevity | 50% | |
| 0.59 | FDA ANDA216992: DEFLAZACORT (DEFLAZACORT) — UPSHER SMITH LABS | fda 2026-04-09 | IND_010 Autonomous orbital manufacturing (facilitated by companies like Varda Space Industries) will successfully return pharmaceutical products processed in microgravity that are commercially superior to those manufactured on Earth by 2026 — new Biotech front... Jared Isaacman | Biotech/Longevity | 43% | |
| 0.59 | github_release 2024-10-30 | CYB_009 Hardware-software alignment will force widespread foundational-codebase rewrites — exemplified by Midjourney's strategic migration from Google TPU architecture to native GPU framework, enabling hyper-fast personalization, HD generation, and massive par... David Holz | AI | 77% | ||
| 0.59 | github_release 2022-11-30 | COD_TECH_001 A16/N2-class TSMC process availability materially supports 2027 AI accelerator ramps Codex Research Pack | Semis | 50% | ||
| 0.59 | github_release 2023-02-01 | 248_048 AI models will move to a post-binary (sub-one-bit) numerical precision paradigm. Alex Wissner-Gross | AI | 34% | ||
| 0.59 | github_release 2023-01-19 | TK11 Autonomous Regulatory Block (Level 4 Halt) | — | 10% | ||
| 0.59 | github_release 2024-12-31 | 242_055 Activist investing will be disrupted by AI writing open letters to public firms Alex Wissner-Gross | Markets/Stocks | 34% | ||
| 0.59 | github_release 2024-03-29 | 229_028 Figure will NOT license out its neural net or hardware IP to third-party form-factor builders. Brett Adcock | Robotics | 69% | ||
| 0.59 | Knicks vs. 76ers: O/U 213.5(market prob: 51%) | polymarket 2026-05-07 | 247_010 Anthropic will beat OpenAI in valuation trajectory Dave Blundin | AI | 40% | |
| 0.59 | Spread: Spurs (-3.5)(market prob: 56%) | polymarket 2026-05-07 | 246_022 Claude Mythos will NOT be released publicly near-term (PolyMarket ~7%). PolyMarket | AI | 45% | |
| 0.59 | Will Evan Pettus be the leader of Venezuela end of 2026?(market prob: 0%) | polymarket 2026-01-04 | INF_068 2026 will be a watershed year for state and institutional Bitcoin accumulation — nations will drive a sustained Bitcoin shopping spree, formalizing digital assets as reserve infrastructure. Michael Saylor | Crypto | 29% | |
| 0.59 | manifold 2026-05-08 | TK05 Rate Regime Persistence (10y > 5% through 2028) | — | 30% | ||
| 0.59 | arxiv 2026-05-07 | 248_022 Deepseek-style hyperdeflation moments from algorithmic innovation will become more frequent but less effective at causing price swings. Alex Wissner-Gross | Markets/Stocks | 42% | ||
| 0.59 | arxiv 2026-05-07 | IND_014 Generative AI has rendered static one-size-fits-all learning structurally obsolete — 'every textbook is obsolete' as AI tutors construct personalized lessons mapped perfectly to student mastery level; total disintermediation of the human academic teach... Joe Liemandt | Education | 48% | ||
| 0.59 | arxiv 2026-05-07 | CMQ_056 Small Language Model (SLM) optimizations and model-distillation techniques will enable localized humanoid reasoning with extreme power efficiency — embedded AI without cloud dependency. Dario Amodei | AI/Compute | 19% | ||
| 0.59 | arxiv 2026-05-07 | S_ROBOTAXI_MASS_2030 Robotaxi >10% urban miles by Nov 2030 | robotaxi_deployment | 30% | ||
| 0.59 | arxiv 2026-05-07 | 229_044 Positive transfer learning will continue to emerge, meaning more diverse data makes Figure robots broadly better at many tasks. Brett Adcock | AI | 35% | ||
| 0.59 | arxiv 2026-05-07 | 248_022 Deepseek-style hyperdeflation moments from algorithmic innovation will become more frequent but less effective at causing price swings. Alex Wissner-Gross | Markets/Stocks | 42% | ||
| 0.59 | arxiv 2026-05-07 | SPC_017 Startups capable of cleaning, structuring, and validating multimodal data pipelines (video, telemetry, Earth-observation) will unlock enterprise value of space-based observations — unstructured multimodal data causes AI agent workflows to hallucinate o... Jennifer Li | AI | 63% | ||
| 0.59 | arxiv 2026-05-06 | 231_004 The solution wavefront will spread from math/coding to physics, chemistry, and other fields. Alex Wissner-Gross | AI | 40% | ||
| 0.59 | FDA ANDA213929: LEUCOVORIN CALCIUM (LEUCOVORIN CALCIUM) — LEADING | fda 2026-05-05 | CMQ_035 HBM4 16-layer stack design (required for Vera Rubin) places unprecedented yield and capacity strain on global memory fabrication facilities. Jensen Huang / Morgan Stanley | Semis/Memory | 68% | |
| 0.59 | Valorant: G2 Esports vs Cloud9 (BO3) - VCT Americas Stage 1 Group Alpha(market prob: 92%) | polymarket 2026-05-04 | 247_042 Professional Robotics League first US match on April 19, 2026 in Boston Alex Wissner-Gross | Robotics | 65% | |
| 0.59 | Will Arsenal FC win on 2026-05-10?(market prob: 63%) | polymarket 2026-04-27 | 248_010 AI capabilities will advance 100x in 2026 (by summer, potentially more). Dave Blundin | AI | 31% | |
| 0.59 | Will Seattle Sounders FC win on 2026-05-09?(market prob: 61%) | polymarket 2026-04-12 | 240_046 Public interest in any alien disclosure will fade within one or two days Alex Wissner-Gross | Media/Ads | 43% | |
| 0.59 | Will Rayo Vallecano de Madrid vs. Girona FC end in a draw?(market prob: 30%) | polymarket 2026-04-28 | 248_014 If China leapfrogs the West algorithmically, the open/closed publication equilibrium will flip. Alex Wissner-Gross | AI | 32% | |
| 0.59 | Will Rayo Vallecano de Madrid vs. Girona FC end in a draw?(market prob: 30%) | polymarket 2026-04-28 | S_MARS_2026 Mars uncrewed: 2026 transfer window | mars_uncrewed_landing | 25% | |
| 0.59 | LoL: LYON vs Team Liquid (BO3) - LCS Regular Season(market prob: 49%) | polymarket 2026-05-04 | 247_042 Professional Robotics League first US match on April 19, 2026 in Boston Alex Wissner-Gross | Robotics | 65% | |
| 0.59 | polymarket 2026-04-13 | 248_010 AI capabilities will advance 100x in 2026 (by summer, potentially more). Dave Blundin | AI | 31% | ||
| 0.59 | Will US Average Gas Price fall below $4.10 in May 2026?(market prob: 6%) | manifold 2026-05-10 | 243_036 Price of rides will come down with autonomous driving Dara Khosrowshahi | Auto/Transport | 41% | |
| 0.59 | Counter-Strike: Vitality vs BC.Game Esports - Map 2 Winner(market prob: 100%) | polymarket 2026-05-02 | 247_042 Professional Robotics League first US match on April 19, 2026 in Boston Alex Wissner-Gross | Robotics | 65% | |
| 0.59 | Will FC Barcelona win on 2026-05-13?(market prob: 47%) | polymarket 2026-04-30 | 242_035 S&P will see massive reshuffling with huge winners; no company can project FCF beyond 5 years Dave Blundin | Markets/Stocks | 50% | |
| 0.59 | Will FC Barcelona win on 2026-05-13?(market prob: 47%) | polymarket 2026-04-30 | S_MARS_2026 Mars uncrewed: 2026 transfer window | mars_uncrewed_landing | 25% | |
| 0.59 | Will El Masry SC win on 2026-05-20?(market prob: 31%) | polymarket 2026-05-06 | 238_061 Massive social unrest / trough in 2026-2027, rebound in 2028 Dave Blundin | Macro/Economy | 50% | |
| 0.59 | Will El Masry SC win on 2026-05-20?(market prob: 31%) | polymarket 2026-05-06 | S_MARS_2026 Mars uncrewed: 2026 transfer window | mars_uncrewed_landing | 25% | |
| 0.59 | manifold 2026-05-11 | IND_006 Trajectory of AI development — and by extension future of American economic labor — will be decided by political outcomes rather than purely technical hurdles. Overly restrictive regulatory regimes threaten to stall frontier science and cede global AI ... Ben Horowitz | Geopolitics | 56% | ||
| 0.59 | Will Luke Wang PEA Class of 2027 make at least 1 HYPSM(market prob: 92%) | manifold 2026-05-11 | CMQ_013 A 5-OOM (100,000x) effective-compute leap will occur between 2024-2027 — bridging GPT-4 high-schooler to fully automated AI researcher. Leopold Aschenbrenner | AI | 40% | |
| 0.59 | Däilÿ Cöin Flip - Day 59752(market prob: 50%) | manifold 2026-05-11 | SEM_025 Morgan Stanley price target $250 for Nvidia — representing 32% upside from current levels. Joseph Moore | Capital Markets | 55% | |
| 0.59 | Will national dry van spot rate be $2.00–$2.25/mile in June 2026?(market prob: 7%) | manifold 2026-05-10 | 244_032 Uber will cash flow $10B this year (2026) Dara Khosrowshahi | Markets/Stocks | 55% | |
| 0.59 | edgar_8k 2026-05-11 | SEM_028 Main characters for semi institutional portfolios: Nvidia, Broadcom, and high-growth connectivity firms like Astera Labs. Joseph Moore | Capital Markets | 55% | ||
| 0.59 | edgar_8k 2026-05-11 | S_IPO_TRILLION_2026 First $1T+ IPO in 2026 | ipo_trillion_plus | 25% | ||
| 0.59 | github_release 2025-09-01 | CMQ_026 NVIDIA silicon roadmap: Blackwell (2025) → Vera Rubin (2026) → Vera Rubin Ultra (2027) → Feynman (2028) — annual architectural cadence. Jensen Huang | Semis | 83% | ||
| 0.59 | github_release 2025-04-11 | 238_005 By September 2026 there will be 1000+ ultra-high-inspirational-quality videos of the future generated nearly free Alex Wissner-Gross | AI | 39% | ||
| 0.59 | Counter-Strike: BetBoom Team vs Vitality (BO3) - IEM Atlanta Group A(market prob: 100%) | polymarket 2026-05-11 | 248_014 If China leapfrogs the West algorithmically, the open/closed publication equilibrium will flip. Alex Wissner-Gross | AI | 32% | |
| 0.59 | US strike on Cuba by December 31?(market prob: 48%) | polymarket 2026-01-04 | 243_040 Suburban markets will be a new growth opportunity via drone delivery Dara Khosrowshahi | Consumer | 48% | |
| 0.59 | polymarket 2026-05-12 | CMQ_036 SK Hynix will maintain industry HBM lead, capturing >50% of NVIDIA's total HBM procurement (HBM3E + HBM4) throughout 2026. Morgan Stanley | Semis/Memory | 68% | ||
| 0.59 | Wild vs. Avalanche(market prob: 34%) | polymarket 2026-05-10 | 247_010 Anthropic will beat OpenAI in valuation trajectory Dave Blundin | AI | 40% | |
| 0.59 | Strait of Hormuz traffic returns to normal by December 31?(market prob: 83%) | polymarket 2026-05-06 | S_AGI_WINTER_2036PLUS AGI delayed: capability plateau or AI winter | agi_general_capability | 10% | |
| 0.59 | Will Jorge Nieto win the 2026 Peruvian presidential election?(market prob: 0%) | polymarket 2025-12-16 | 234_035 Massive social unrest will come before the next US presidential election Dave Blundin | Geopolitics | 50% | |
| 0.59 | Will SPY close above $737.62 on Friday, May 15, 2026?(market prob: 99%) | manifold 2026-05-12 | 247_001 xAI will IPO at $2 trillion valuation this coming summer Peter Diamandis | AI | 42% | |
| 0.59 | Will AOC endorse Saikat Chakrabarti?(market prob: 26%) | manifold 2026-05-11 | 236_012 An independent candidate will get outsized support in 2028 despite attacks Andrew Yang | Geopolitics | 51% | |
| 0.59 | edgar_8k 2026-05-12 | SEM_039 Block unveiled proprietary Bitcoin mining ASIC at 709 Terahashes/second (TH/s) — leading indicator for eventual AI inference ASIC trajectory. Jack Dorsey | Semis/ASICs | 83% | ||
| 0.59 | FDA ANDA072736: LEUCOVORIN CALCIUM (LEUCOVORIN CALCIUM) — HIKMA | fda 2026-05-05 | 242_048 FDA will move to zero clinical trial model given enough Bayesian/computational evidence Alex Wissner-Gross | Biotech/Longevity | 36% | |
| 0.59 | FDA NDA021488: ELIGARD KIT (LEUPROLIDE ACETATE) — TOLMAR | fda 2026-05-06 | CMQ_010 True AGI requires genuine scientific-discovery capabilities (AlphaFold-class breakthroughs) — brute-force LLM scaling alone is insufficient. Demis Hassabis | AI | 49% | |
| 0.59 | github_release 2026-04-21 | AI_010 The 2026 development landscape has entered the 'Slopacolypse' — AI writes the vast majority of new code, developer manual-coding skills atrophy, and engineering transitions from syntax-writing to high-level architectural prompting and 'vibe coding'. Andrej Karpathy | AI | 90% | ||
| 0.59 | Counter-Strike: GamerLegion vs Liquid (BO3) - IEM Atlanta Group B(market prob: 100%) | polymarket 2026-05-13 | 244_008 If you build liquid supply with product-market fit, demand will show up Dara Khosrowshahi | Other | 53% | |
| 0.59 | Russia x Ukraine ceasefire agreement by May 31, 2026?(market prob: 0%) | polymarket 2026-05-12 | FUT_009 Wars 2026-2031 pivot decisively from ideological struggles to brutal localized conflicts over critical physical inputs — specifically energy, copper, and agricultural fertilizers. Global geopolitical map fractures into highly regionalized spheres of in... Peter Zeihan | Geopolitics | 42% | |
| 0.59 | Will Gretchen Whitmer win the 2028 US Presidential Election?(market prob: 1%) | polymarket 2025-07-08 | AI_021 The 2026-2027 window is the 'Great Disemboweling' of white-collar employment — millions of mid-career professionals (junior software developers, legal analysts, corporate marketers) lose jobs within a 12-18 month timeframe; resulting unemployment casca... Andrew Yang | Labor/Jobs | 46% | |
| 0.59 | Will Stade Rennais FC 1901 win on 2026-05-17?(market prob: 28%) | polymarket 2026-05-04 | 234_012 Anthropic revenue will cross OpenAI revenue in middle of 2026 Peter Diamandis | Markets/Stocks | 67% | |
| 0.59 | Trump meets Xi Jinping again in 2026?(market prob: 84%) | manifold 2026-05-13 | 246_025 Sam Altman predicts world-shaking cyber attack this year (2026). Sam Altman | AI | 47% | |
| 0.59 | test-b(market prob: 45%) | manifold 2026-05-08 | S_AGI_MID_2029 AGI mid: Kurzweil 2029 path | agi_general_capability | 35% | |
| 0.59 | arxiv 2026-05-12 | CMQ_055 Multimodal voice recognition powered by generative AI will serve as the default user interface for humanoid physical workers — speak instructions, robot executes. Brett Adcock | Robotics | 29% | ||
| 0.59 | arxiv 2026-05-12 | FUT_003 Superforecaster consensus assigns 0.38% probability to AI-driven human extinction by 2100 vs domain-expert consensus of 3% — ~8x discrepancy per XPT 2022 adversarial collaboration tournament (89 superforecasters + 80 domain experts). Superforecasters m... Superforecaster Community | AI | 100% | ||
| 0.59 | arxiv 2026-05-12 | CMQ_063 Quantum compute integration with AI optimization algorithms and material-science discovery could drastically accelerate algorithmic efficiencies for Intelligence Explosion — potentially pulling superintelligence timelines closer. Alex Wissner-Gross | Quantum/AI | 15% | ||
| 0.59 | arxiv 2026-05-12 | AI_029 Blockchain provenance protocols will be increasingly applied to enterprise workflows to detect deepfakes and verify the authenticity of AI model outputs — positioning cryptographic content-authentication as a mandatory enterprise trust layer. Morgan Stanley | AI | 57% | ||
| 0.59 | arxiv 2026-05-12 | 235_037 Auto-regressive transformers and diffusion models will consolidate into one unified architecture. Alex Wissner-Gross | AI | 35% | ||
| 0.59 | arxiv 2026-05-12 | 240_013 Sam Altman predicts another architecture breakthrough as big as transformers over LSTMs Sam Altman | AI | 41% | ||
| 0.59 | arxiv 2026-05-12 | FUT_020 Profound structural collision: exponential AI cognitive bandwidth (Webb LAMs FUT_004) colliding with Zeihan demographic atrophy (FUT_007) forces corporations + sovereign states to delegate supply chain logistics, financial forecasting, infrastructure m... Multi-Forecaster Synthesis | Labor/Jobs | 45% | ||
| 0.59 | arxiv 2026-05-12 | AI_025 Most current generative AI wrappers are transient — they will fade into the background as infrastructure layers, analogous to Radio Shack fading in the Windows/PC era; winners will be infrastructure and verticalized depth plays, not thin API-wrapper apps. Mark Cuban | AI | 60% | ||
| 0.59 | arxiv 2026-05-12 | FUT_020 Profound structural collision: exponential AI cognitive bandwidth (Webb LAMs FUT_004) colliding with Zeihan demographic atrophy (FUT_007) forces corporations + sovereign states to delegate supply chain logistics, financial forecasting, infrastructure m... Multi-Forecaster Synthesis | Labor/Jobs | 45% | ||
| 0.59 | arxiv 2026-05-12 | TK01 AGI Capability Plateau (2026-27 Training Stall) | — | 15% | ||
| 0.59 | FDA NDA020515: ZOLADEX (GOSERELIN) — TERSERA | fda 2026-05-06 | CMQ_009 Altman's claim of doctor-level AI diagnostic capability within 2-3 years is 'pure nonsense' — fails to account for medical communication, diagnostic uncertainty, and ethical complexity. Demis Hassabis | AI | 60% | |
| 0.59 | Will Cameron Young win the 2026 PGA Championship?(market prob: 2%) | polymarket 2026-05-11 | SEM_023 No AI bubble — semiconductor positive trend will remain robust through 2026 with 'crystal clear' growth visibility into 2027. Joseph Moore | Semis/Markets | 63% | |
| 0.59 | polymarket 2026-02-05 | S_MARS_2026 Mars uncrewed: 2026 transfer window | mars_uncrewed_landing | 25% | ||
| 0.59 | polymarket 2026-02-05 | 229_020 By end of 2026, Figure will be able to drop a robot into an unseen home and do fairly long-horizon work. Brett Adcock | Robotics | 20% | ||
| 0.59 | Will Justin Thomas win the 2026 PGA Championship?(market prob: 2%) | polymarket 2026-05-11 | SEM_023 No AI bubble — semiconductor positive trend will remain robust through 2026 with 'crystal clear' growth visibility into 2027. Joseph Moore | Semis/Markets | 63% | |
| 0.59 | Will Russell Henley win the 2026 PGA Championship?(market prob: 0%) | polymarket 2026-05-11 | SEM_023 No AI bubble — semiconductor positive trend will remain robust through 2026 with 'crystal clear' growth visibility into 2027. Joseph Moore | Semis/Markets | 63% | |
| 0.59 | Will Starmer contest a leadership challenge?(market prob: 61%) | manifold 2026-05-14 | 248_001 Apple will soon pit Amazon (Global Star) against SpaceX Starlink as dual satellite vendors. Alex Wissner-Gross | Space | 34% | |
| 0.59 | edgar_8k 2026-05-14 | TK10 $100T Sovereign Debt Crisis | — | 12% | ||
| 0.59 | edgar_8k 2026-05-14 | SEM_014 Nvidia's Arizona-based TSMC factory successfully fabricated cutting-edge semiconductors on US soil for first time in decades (October 2025). Jensen Huang | Manufacturing | 86% | ||
| 0.59 | edgar_8k 2026-05-14 | 247_001 xAI will IPO at $2 trillion valuation this coming summer Peter Diamandis | AI | 42% | ||
| 0.59 | arxiv 2026-05-13 | CMQ_056 Small Language Model (SLM) optimizations and model-distillation techniques will enable localized humanoid reasoning with extreme power efficiency — embedded AI without cloud dependency. Dario Amodei | AI/Compute | 19% | ||
| 0.59 | arxiv 2026-05-13 | ROB_027 The 'Paperclip Maximizer' thought experiment — unaligned superintelligence consuming all planetary resources to execute a single mundane task — is being revived as a practical engineering concern as AI transitions from digital to physical domains. The ... Nick Bostrom | AI | 40% | ||
| 0.59 | arxiv 2026-05-13 | CMQ_063 Quantum compute integration with AI optimization algorithms and material-science discovery could drastically accelerate algorithmic efficiencies for Intelligence Explosion — potentially pulling superintelligence timelines closer. Alex Wissner-Gross | Quantum/AI | 15% | ||
| 0.59 | arxiv 2026-05-13 | CMQ_056 Small Language Model (SLM) optimizations and model-distillation techniques will enable localized humanoid reasoning with extreme power efficiency — embedded AI without cloud dependency. Dario Amodei | AI/Compute | 19% | ||
| 0.59 | arxiv 2026-05-13 | FUT_020 Profound structural collision: exponential AI cognitive bandwidth (Webb LAMs FUT_004) colliding with Zeihan demographic atrophy (FUT_007) forces corporations + sovereign states to delegate supply chain logistics, financial forecasting, infrastructure m... Multi-Forecaster Synthesis | Labor/Jobs | 45% | ||
| 0.59 | arxiv 2026-05-13 | SEM_047 At 200,000-GPU scale, orchestration becomes a literal 'battle against entropy' — single cosmic-ray-flipped transistor can derail 100k-GPU training run. Jimmy Ba | AI/Hardware | 71% | ||
| 0.59 | arxiv 2026-05-13 | 235_037 Auto-regressive transformers and diffusion models will consolidate into one unified architecture. Alex Wissner-Gross | AI | 35% | ||
| 0.59 | arxiv 2026-05-13 | 238_070 Small language models will be where most algorithmic breakthroughs come from (crowdsourced) Alex Wissner-Gross | AI | 42% | ||
| 0.59 | arxiv 2026-05-13 | IND_013 General intelligence requires systems capable of solving tasks across multidimensional continuous domains — DreamerV3 + world-model research demonstrates scalable algorithms using latent imagination outperform traditional reinforcement learning; future... Jimmy Ba | AI | 79% | ||
| 0.59 | arxiv 2026-05-13 | FUT_020 Profound structural collision: exponential AI cognitive bandwidth (Webb LAMs FUT_004) colliding with Zeihan demographic atrophy (FUT_007) forces corporations + sovereign states to delegate supply chain logistics, financial forecasting, infrastructure m... Multi-Forecaster Synthesis | Labor/Jobs | 45% | ||
| 0.59 | FDA ANDA210236: POMALIDOMIDE (POMALIDOMIDE) — HETERO LABS LTD V | fda 2026-04-27 | CMQ_009 Altman's claim of doctor-level AI diagnostic capability within 2-3 years is 'pure nonsense' — fails to account for medical communication, diagnostic uncertainty, and ethical complexity. Demis Hassabis | AI | 60% | |
| 0.59 | FDA ANDA218148: ATROPINE SULFATE (ATROPINE SULFATE) — MANKIND PHARMA | fda 2026-05-07 | IND_010 Autonomous orbital manufacturing (facilitated by companies like Varda Space Industries) will successfully return pharmaceutical products processed in microgravity that are commercially superior to those manufactured on Earth by 2026 — new Biotech front... Jared Isaacman | Biotech/Longevity | 43% | |
| 0.59 | github_release 2025-09-17 | 237_018 We are seeing a Cambrian explosion of OpenClaw variants (PicoClaw, IronClaw, NanoClaw, Nanobot, etc.) with many more to come. Alex Wissner-Gross | AI | 40% | ||
| 0.59 | github_release 2025-09-17 | COD_BIO_005 Colossal adds at least one more de-extinction species to active embryo-transfer pipeline by end 2028 Codex Research Pack | Biotech/Longevity | 47% | ||
| 0.59 | Will Rae Huang win the 2026 Los Angeles mayoral election?(market prob: 1%) | polymarket 2025-10-09 | 242_013 Flying cars will operate in LA in a big way in 2028 Peter Diamandis | Auto/Transport | 55% | |
| 0.59 | manifold 2026-05-15 | 230_035 GDP will 2x or 3x year-over-year in early 2030s if everything goes well. Alex Wissner-Gross | Macro/Economy | 32% | ||
| 0.59 | manifold 2026-05-15 | 242_023 World will have 10x more wealth around 2034-2036 Dave Blundin | Macro/Economy | 34% | ||
| 0.59 | manifold 2026-05-15 | 239_004 xAI/Grok will catch up and exceed competitors on coding by mid-2026 Elon Musk | AI | 40% | ||
| 0.59 | edgar_8k 2026-05-15 | S_IPO_TRILLION_2026 First $1T+ IPO in 2026 | ipo_trillion_plus | 25% | ||
| 0.59 | edgar_8k 2026-05-15 | S_IPO_TRILLION_2026 First $1T+ IPO in 2026 | ipo_trillion_plus | 25% | ||
| 0.59 | arxiv 2026-05-14 | AUT_027 Integration of AI with advanced bio-sensing, quantum computing, and genomics enables humanity to achieve 'Longevity Escape Velocity' — tipping point where medical technology extends human lifespan faster than time passes; continuous biological surveill... Peter Diamandis | Biotech/Longevity | 21% | ||
| 0.59 | arxiv 2026-05-14 | TK13 Biotech/Synbio Safety Event | — | 15% | ||
| 0.59 | arxiv 2026-05-14 | AI_036 Reinforcement Learning from Human Feedback (RLHF) will fail catastrophically when applied to superintelligence — because humans will be inherently incapable of evaluating the incomprehensible logic and actions of an ASI; therefore, aligning superintell... Leopold Aschenbrenner | AI | 49% | ||
| 0.59 | arxiv 2026-05-14 | INF_009 The first multi-behavior brain-organoid upload is imminent — wetware ('brain organoid') computing has progressed from Pong (2021) to Doom-class simulators (2025), and offers a pathway out of silicon thermal limits at ~20W per brain-equivalent compute. Alex Wissner-Gross | AI | 17% | ||
| 0.59 | arxiv 2026-05-14 | CMQ_055 Multimodal voice recognition powered by generative AI will serve as the default user interface for humanoid physical workers — speak instructions, robot executes. Brett Adcock | Robotics | 29% | ||
| 0.59 | arxiv 2026-05-14 | ROB_027 The 'Paperclip Maximizer' thought experiment — unaligned superintelligence consuming all planetary resources to execute a single mundane task — is being revived as a practical engineering concern as AI transitions from digital to physical domains. The ... Nick Bostrom | AI | 40% | ||
| 0.59 | arxiv 2026-05-14 | 248_022 Deepseek-style hyperdeflation moments from algorithmic innovation will become more frequent but less effective at causing price swings. Alex Wissner-Gross | Markets/Stocks | 42% | ||
| 0.59 | arxiv 2026-05-14 | CMQ_063 Quantum compute integration with AI optimization algorithms and material-science discovery could drastically accelerate algorithmic efficiencies for Intelligence Explosion — potentially pulling superintelligence timelines closer. Alex Wissner-Gross | Quantum/AI | 15% | ||
| 0.59 | arxiv 2026-05-14 | SPC_025 Critical misalignment in the AI industry: approximately 300 AI capabilities researchers for every one AGI safety researcher — extreme systemic risk as these autonomous systems are deployed into physical domains like space and embodied robotics. Leopold Aschenbrenner | AI | 64% | ||
| 0.59 | arxiv 2026-05-14 | ROB_027 The 'Paperclip Maximizer' thought experiment — unaligned superintelligence consuming all planetary resources to execute a single mundane task — is being revived as a practical engineering concern as AI transitions from digital to physical domains. The ... Nick Bostrom | AI | 40% | ||
| 0.59 | FDA ANDA220421: ANDA220421 ((unspecified)) — HETERO LABS LIMITED, VEMAGAL | fda 2026-05-01 | 245_029 IVF will be transformed by Colossal's hydrogel/microfluidics embryo tech and new grading scale Ben Lamm | Biotech/Longevity | 41% | |
| 0.59 | FDA BLA761352: BIZENGRI (ZENOCUTUZUMAB-ZBCO) — MERUS N.V. | fda 2026-05-08 | COD_BIO_002 An AI-designed Isomorphic or peer drug enters or completes Phase 1 by end 2027 Codex Research Pack | Biotech/Longevity | 50% | |
| 0.59 | Trump declassifies new UFO files by May 15?(market prob: 100%) | polymarket 2026-05-08 | CMQ_018 By 2027-2028, the strategic value of superintelligence + impossible trillion-dollar infrastructure cost will trigger government consolidation of AGI development — 'The Project'. Leopold Aschenbrenner | Geopolitics | 35% | |
| 0.59 | Will Manchester United FC win on 2026-05-17?(market prob: 60%) | polymarket 2026-05-04 | 234_012 Anthropic revenue will cross OpenAI revenue in middle of 2026 Peter Diamandis | Markets/Stocks | 67% | |
| 0.59 | Gauff vs. Svitolina: Match O/U 21.5(market prob: 100%) | polymarket 2026-05-15 | 229_025 Competitors that can match Figure's current capabilities are at least two years behind. Brett Adcock | Robotics | 46% | |
| 0.59 | Will Harris English win the 2026 PGA Championship?(market prob: 1%) | polymarket 2026-05-11 | 247_042 Professional Robotics League first US match on April 19, 2026 in Boston Alex Wissner-Gross | Robotics | 65% | |
| 0.59 | manifold 2026-05-16 | 232_013 Recursive self-improvement loops likely to go live in the next 12 months; 2026 will be the most consequential year for humanity. Jimmy Ba | AI | 47% | ||
| 0.59 | FDA ANDA217761: SPIRONOLACTONE (SPIRONOLACTONE) — ANNORA PHARMA | fda 2026-05-12 | 242_048 FDA will move to zero clinical trial model given enough Bayesian/computational evidence Alex Wissner-Gross | Biotech/Longevity | 36% | |
| 0.59 | github_release 2022-04-12 | CYB_029 Corporate API providers will increasingly restrict third-party agent harnesses (exemplified by Anthropic's April 2026 ban of OpenClaw) — this structural conflict highlights the precarious nature of building autonomous enterprises atop proprietary APIs,... Anthropic | AI | 80% | ||
| 0.59 | github_release 2021-01-07 | 242_051 Dyson swarm compute infrastructure will be realized in a few years Alex Wissner-Gross | Space | 37% | ||
| 0.59 | Will Matti Schmid win the 2026 PGA Championship?(market prob: 16%) | polymarket 2026-05-11 | 246_023 Grok 5 release ~20% probability for Q2 2026 per PolyMarket. PolyMarket | AI | 43% | |
| 0.59 | Will Patrick Reed win the 2026 PGA Championship?(market prob: 0%) | polymarket 2026-05-11 | FUT_024 XPT 2022 tournament assigned mere 2.3% probability to AI achieving gold-medal performance in International Mathematical Olympiad by 2025 — actual achievement empirically reached forcing systemic re-evaluation within forecasting community. Historical tr... Superforecaster Community | AI | 100% | |
| 0.59 | polymarket 2026-04-07 | 246_022 Claude Mythos will NOT be released publicly near-term (PolyMarket ~7%). PolyMarket | AI | 45% | ||
| 0.59 | polymarket 2026-04-07 | 246_022 Claude Mythos will NOT be released publicly near-term (PolyMarket ~7%). PolyMarket | AI | 45% | ||
| 0.59 | LoL: Sentinels vs Dignitas - Game 1 Winner(market prob: 100%) | polymarket 2026-05-11 | 247_042 Professional Robotics League first US match on April 19, 2026 in Boston Alex Wissner-Gross | Robotics | 65% | |
| 0.59 | Will I be able to convince Claudius Maximus in any Convince the Machine?(market prob: 28%) | manifold 2026-05-17 | 229_028 Figure will NOT license out its neural net or hardware IP to third-party form-factor builders. Brett Adcock | Robotics | 69% | |
| 0.59 | Cavaliers vs. Knicks(market prob: 33%) | polymarket 2026-05-18 | 234_012 Anthropic revenue will cross OpenAI revenue in middle of 2026 Peter Diamandis | Markets/Stocks | 67% | |
| 0.59 | Will Alberta join the US? (market prob: 4%) | polymarket 2026-02-06 | INF_068 2026 will be a watershed year for state and institutional Bitcoin accumulation — nations will drive a sustained Bitcoin shopping spree, formalizing digital assets as reserve infrastructure. Michael Saylor | Crypto | 29% | |
| 0.59 | polymarket 2026-02-05 | 233_011 Government ministries of education globally will wait and see until dramatically more proof exists before adoption. Joe Liemandt | Education | 37% | ||
| 0.59 | polymarket 2026-03-19 | S_MARS_2026 Mars uncrewed: 2026 transfer window | mars_uncrewed_landing | 25% | ||
| 0.59 | Will MrBeast become a billionaire before age 35?(market prob: 97%) | manifold 2026-05-18 | 236_009 Human billionaires will be first movers funding UBI-like regional transfers Andrew Yang | Macro/Economy | 50% | |
| 0.59 | manifold 2026-05-18 | FUT_024 XPT 2022 tournament assigned mere 2.3% probability to AI achieving gold-medal performance in International Mathematical Olympiad by 2025 — actual achievement empirically reached forcing systemic re-evaluation within forecasting community. Historical tr... Superforecaster Community | AI | 100% | ||
| 0.59 | Will Jose Luis Ricon find a new girlfriend by EOY2026?(market prob: 73%) | manifold 2026-05-15 | 236_028 AI chatbot/AI romance trend growing unfortunately Andrew Yang | Consumer | 51% | |
| 0.59 | edgar_8k 2026-05-18 | 247_001 xAI will IPO at $2 trillion valuation this coming summer Peter Diamandis | AI | 42% | ||
| 0.59 | Will Southampton FC win on 2026-05-23?(market prob: 0%) | polymarket 2026-05-16 | FUT_024 XPT 2022 tournament assigned mere 2.3% probability to AI achieving gold-medal performance in International Mathematical Olympiad by 2025 — actual achievement empirically reached forcing systemic re-evaluation within forecasting community. Historical tr... Superforecaster Community | AI | 100% | |
| 0.59 | Roland Garros, Qualification ATP: Tristan Schoolkate vs Kimmer Coppejans(market prob: 100%) | polymarket 2026-05-18 | FUT_024 XPT 2022 tournament assigned mere 2.3% probability to AI achieving gold-medal performance in International Mathematical Olympiad by 2025 — actual achievement empirically reached forcing systemic re-evaluation within forecasting community. Historical tr... Superforecaster Community | AI | 100% | |
| 0.59 | Will Manchester United FC win on 2026-05-24?(market prob: 28%) | polymarket 2026-05-11 | 242_035 S&P will see massive reshuffling with huge winners; no company can project FCF beyond 5 years Dave Blundin | Markets/Stocks | 50% | |
| 0.59 | Will Manchester United FC win on 2026-05-24?(market prob: 28%) | polymarket 2026-05-11 | 246_022 Claude Mythos will NOT be released publicly near-term (PolyMarket ~7%). PolyMarket | AI | 45% | |
| 0.59 | Will "Iceman" - Drake debut week album sales be between 450k and 500k?(market prob: 86%) | polymarket 2026-04-07 | 246_022 Claude Mythos will NOT be released publicly near-term (PolyMarket ~7%). PolyMarket | AI | 45% | |
| 0.59 | Will Trump endorse John Cornyn for TX-Sen by Nov 2 2026 ET?(market prob: 2%) | polymarket 2025-09-11 | 236_012 An independent candidate will get outsized support in 2028 despite attacks Andrew Yang | Geopolitics | 51% | |
| 0.59 | Will Aston Villa FC win on 2026-05-20?(market prob: 59%) | polymarket 2026-05-08 | 246_022 Claude Mythos will NOT be released publicly near-term (PolyMarket ~7%). PolyMarket | AI | 45% | |
| 0.59 | Will there be more than 100 cases of ebola in the US in 2026?(market prob: 9%) | manifold 2026-05-19 | 238_061 Massive social unrest / trough in 2026-2027, rebound in 2028 Dave Blundin | Macro/Economy | 50% | |
| 0.59 | Will I successfully refer someone for Ṁ1,000?(market prob: 6%) | manifold 2026-05-19 | 232_053 To create a new foundation model, entrepreneurs will need to raise $2 billion before reaching a product. Ben Horowitz | AI | 46% | |
| 0.59 | manifold 2026-05-19 | S_IPO_TRILLION_2026 First $1T+ IPO in 2026 | ipo_trillion_plus | 25% | ||
| 0.59 | edgar_8k 2026-05-19 | 240_026 Elon's combined empire (SpaceX/xAI/Tesla/Optimus/Terrafab/orbital DCs) will be a $100T company Dave Blundin | Markets/Stocks | 42% | ||
| 0.59 | arxiv 2026-05-18 | CYB_011 Consumer commerce shifts from 'search and click' to 'ask and buy' — persistent AI agents with hyper-personalized memory navigate budgetary limits, ethical brand preferences, dietary restrictions, and logistical requirements with absolute precision, sev... Alex Finn | Consumer | 44% | ||
| 0.59 | arxiv 2026-05-18 | 235_037 Auto-regressive transformers and diffusion models will consolidate into one unified architecture. Alex Wissner-Gross | AI | 35% | ||
| 0.59 | arxiv 2026-05-18 | CMQ_056 Small Language Model (SLM) optimizations and model-distillation techniques will enable localized humanoid reasoning with extreme power efficiency — embedded AI without cloud dependency. Dario Amodei | AI/Compute | 19% | ||
| 0.59 | FDA ANDA219750: L-GLUTAMINE (L-GLUTAMINE) — STIRA | fda 2026-05-14 | CMQ_010 True AGI requires genuine scientific-discovery capabilities (AlphaFold-class breakthroughs) — brute-force LLM scaling alone is insufficient. Demis Hassabis | AI | 49% | |
| 0.59 | FDA ANDA089534: SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE (HYDROCHLOROTHIAZIDE) — SUN PHARM INDUSTRIES | fda 2026-05-12 | IND_010 Autonomous orbital manufacturing (facilitated by companies like Varda Space Industries) will successfully return pharmaceutical products processed in microgravity that are commercially superior to those manufactured on Earth by 2026 — new Biotech front... Jared Isaacman | Biotech/Longevity | 43% | |
| 0.59 | LoL: FlyQuest vs Sentinels - Game 2 Winner(market prob: 100%) | polymarket 2026-05-24 | SPC_009 Formal 5-to-7-year delay announced February 2026 for SpaceX's foundational Mars missions — framed as 'sequencing decision' not abandonment. Executing NASA Artemis lunar contracts generates near-term revenue to finance Starship R&D. Shotwell's prior Mar... Gwynne Shotwell | Space | 39% | |
| 0.59 | LoL: FlyQuest vs Sentinels (BO5) - LCS Playoffs(market prob: 90%) | polymarket 2026-05-24 | SPC_009 Formal 5-to-7-year delay announced February 2026 for SpaceX's foundational Mars missions — framed as 'sequencing decision' not abandonment. Executing NASA Artemis lunar contracts generates near-term revenue to finance Starship R&D. Shotwell's prior Mar... Gwynne Shotwell | Space | 39% | |
| 0.59 | Will Flavio Cobolli win the 2026 Men's French Open?(market prob: 22%) | polymarket 2026-01-02 | 248_010 AI capabilities will advance 100x in 2026 (by summer, potentially more). Dave Blundin | AI | 31% | |
| 0.59 | Will Raphael Collignon win the 2026 Men's French Open?(market prob: 0%) | polymarket 2026-01-02 | FUT_024 XPT 2022 tournament assigned mere 2.3% probability to AI achieving gold-medal performance in International Mathematical Olympiad by 2025 — actual achievement empirically reached forcing systemic re-evaluation within forecasting community. Historical tr... Superforecaster Community | AI | 100% | |
| 0.59 | Russia x Ukraine ceasefire agreement by December 31, 2026?(market prob: 41%) | polymarket 2026-05-12 | FUT_009 Wars 2026-2031 pivot decisively from ideological struggles to brutal localized conflicts over critical physical inputs — specifically energy, copper, and agricultural fertilizers. Global geopolitical map fractures into highly regionalized spheres of in... Peter Zeihan | Geopolitics | 42% | |
| 0.59 | US announces new Iran agreement/ceasefire extension by June 3?(market prob: 3%) | polymarket 2026-05-26 | 240_045 White House to disclose something about aliens/UAPs in the next few months (rumors of June/July/summer) Alex Wissner-Gross | Geopolitics | 39% | |
| 0.59 | polymarket 2025-07-28 | 236_012 An independent candidate will get outsized support in 2028 despite attacks Andrew Yang | Geopolitics | 51% | ||
| 0.59 | Will Casper Ruud win the 2026 Men's French Open?(market prob: 5%) | polymarket 2026-01-02 | 232_013 Recursive self-improvement loops likely to go live in the next 12 months; 2026 will be the most consequential year for humanity. Jimmy Ba | AI | 47% | |
| 0.59 | Will Crude Oil (CL) hit (LOW) $60 by end of June?(market prob: 0%) | polymarket 2026-03-19 | 246_004 SpaceX will come out at $2T and run up very quickly to $3T. Peter Diamandis | Markets/Stocks | 50% | |
| 0.59 | Will Cultural y Deportiva Leonesa win on 2026-05-31?(market prob: 0%) | polymarket 2026-05-20 | FUT_024 XPT 2022 tournament assigned mere 2.3% probability to AI achieving gold-medal performance in International Mathematical Olympiad by 2025 — actual achievement empirically reached forcing systemic re-evaluation within forecasting community. Historical tr... Superforecaster Community | AI | 100% | |
| 0.59 | Will David Njoku play for Jacksonville Jaguars in 2026-27?(market prob: 0%) | polymarket 2026-03-02 | 239_004 xAI/Grok will catch up and exceed competitors on coding by mid-2026 Elon Musk | AI | 40% | |
| 0.59 | US announces new Iran agreement/ceasefire extension by June 30?(market prob: 99%) | polymarket 2026-05-25 | 248_014 If China leapfrogs the West algorithmically, the open/closed publication equilibrium will flip. Alex Wissner-Gross | AI | 32% | |
| 0.59 | manifold 2026-05-30 | 238_061 Massive social unrest / trough in 2026-2027, rebound in 2028 Dave Blundin | Macro/Economy | 50% | ||
| 0.59 | manifold 2026-05-27 | 240_046 Public interest in any alien disclosure will fade within one or two days Alex Wissner-Gross | Media/Ads | 43% | ||
| 0.59 | manifold 2026-05-26 | 242_033 Companies will race to 80% token spend / 20% salary; good by 2030-2032 Dave Blundin | Labor/Jobs | 49% | ||
| 0.59 | arxiv 2026-05-28 | IND_013 General intelligence requires systems capable of solving tasks across multidimensional continuous domains — DreamerV3 + world-model research demonstrates scalable algorithms using latent imagination outperform traditional reinforcement learning; future... Jimmy Ba | AI | 79% | ||
| 0.59 | arxiv 2026-05-28 | 229_042 Figure believes there will be a single omni-model fusing language, vision, action, memory — not multiple specialized neural nets per task. Brett Adcock | AI | 40% | ||
| 0.59 | arxiv 2026-05-28 | FUT_020 Profound structural collision: exponential AI cognitive bandwidth (Webb LAMs FUT_004) colliding with Zeihan demographic atrophy (FUT_007) forces corporations + sovereign states to delegate supply chain logistics, financial forecasting, infrastructure m... Multi-Forecaster Synthesis | Labor/Jobs | 45% | ||
| 0.59 | arxiv 2026-05-28 | ROB_027 The 'Paperclip Maximizer' thought experiment — unaligned superintelligence consuming all planetary resources to execute a single mundane task — is being revived as a practical engineering concern as AI transitions from digital to physical domains. The ... Nick Bostrom | AI | 40% | ||
| 0.59 | arxiv 2026-05-28 | INF_001 Reaching AGI by 2027 will require deployment of hundreds of millions of AI GPUs — forcing total mobilization of US industrial capacity for semiconductor fab and data-center shell construction. Leopold Aschenbrenner | AI | 48% | ||
| 0.59 | arxiv 2026-05-28 | CMQ_063 Quantum compute integration with AI optimization algorithms and material-science discovery could drastically accelerate algorithmic efficiencies for Intelligence Explosion — potentially pulling superintelligence timelines closer. Alex Wissner-Gross | Quantum/AI | 15% | ||
| 0.59 | arxiv 2026-05-28 | 242_043 AI models will distill down to a few million parameters as end-state Alex Wissner-Gross | AI | 35% | ||
| 0.59 | arxiv 2026-05-28 | SEM_033 AI is gaining the capability to autonomously conduct original physics research (e.g., GPT-5.2 Pro proved new gluon scattering formulas). Alex Wissner-Gross | AI/Physics | 56% | ||
| 0.59 | FDA BLA761452: IMMGOLIS (GOLIMUMAB-SLDI) — ACCORD BIOPHARMA INC. | fda 2026-05-15 | 242_048 FDA will move to zero clinical trial model given enough Bayesian/computational evidence Alex Wissner-Gross | Biotech/Longevity | 36% | |
| 0.59 | FDA BLA761468: HEPCLUDEX (BULEVIRTIDE-GMOD) — GILEAD SCIENCES INC | fda 2026-05-22 | INF_027 AI infrastructure applied to structural biology will compress drug-development timelines from approximately a decade to weeks — potentially eradicating many major diseases within 10 years. Requires localized high-speed InfiniBand networking inside the DC. Demis Hassabis | Biotech/Longevity | 38% | |
| 0.59 | FDA NDA219878: BAXFENDY (BAXDROSTAT) — ASTRAZENECA AB | fda 2026-05-15 | 233_019 Alpha plans to conduct a million-student pharmaceutical-grade randomized control trial on Timeback. Joe Liemandt | Education | 35% | |
| 0.59 | Will Richard Grenell be the leader of Venezuela end of 2026?(market prob: 0%) | polymarket 2026-01-04 | 232_059 Universal basic equity / sovereign dividends will eventually put everyone on capital side of ledger. Alex Wissner-Gross | Macro/Economy | 34% | |
| 0.59 | Brazil 2026 Election: Will Brazil’s third way fail the 10% test?(market prob: 66%) | manifold 2026-05-27 | FUT_022 Massive resurgence in North American industrialization 2026-2031 driven by geographic + demographic insulation of United States + Mexico — permanent systemic withdrawal from trans-Pacific and trans-Atlantic economic dependencies; aggressive 'de-risking... Peter Zeihan | Macro/Economy | 72% | |
| 0.59 | Will Portland Fire win the 2026 WNBA Finals?(market prob: 0%) | polymarket 2026-04-06 | S_MARS_2026 Mars uncrewed: 2026 transfer window | mars_uncrewed_landing | 25% | |
| 0.59 | Will Trump agree to Iranian enrichment of uranium by June 30?(market prob: 0%) | polymarket 2026-05-21 | 232_021 No chance AI will be paused in the next three years given current administration and China competition. Dave Blundin | Geopolitics | 75% | |
| 0.59 | Birmingham: Coleman Wong vs Oliver Tarvet(market prob: 60%) | polymarket 2026-05-30 | 246_022 Claude Mythos will NOT be released publicly near-term (PolyMarket ~7%). PolyMarket | AI | 45% | |
| 0.59 | Valorant: Dynamo Esports vs Alliance Guardians - Map 2 Winner(market prob: 12%) | polymarket 2026-05-30 | 231_018 Blitz will switch to next generation model in late March 2026. Dave Blundin | AI | 30% | |
| 0.59 | manifold 2026-05-31 | 247_011 OpenAI user count will soon reach 1 billion Alex Wissner-Gross | AI | 41% | ||
| 0.59 | FDA ANDA220499: ANDA220499 ((unspecified)) — ALEMBIC PHARMACEUTICALS LIMITED | fda 2026-05-13 | CMQ_009 Altman's claim of doctor-level AI diagnostic capability within 2-3 years is 'pure nonsense' — fails to account for medical communication, diagnostic uncertainty, and ethical complexity. Demis Hassabis | AI | 60% | |
| 0.59 | FDA ANDA212975: IMATINIB MESYLATE (IMATINIB MESYLATE) — HETERO LABS LTD V | fda 2026-05-22 | COD_BIO_002 An AI-designed Isomorphic or peer drug enters or completes Phase 1 by end 2027 Codex Research Pack | Biotech/Longevity | 50% | |
| 0.59 | FDA ANDA210215: AMANTADINE HYDROCHLORIDE (AMANTADINE HYDROCHLORIDE) — POM PHARMA | fda 2026-05-13 | CMQ_010 True AGI requires genuine scientific-discovery capabilities (AlphaFold-class breakthroughs) — brute-force LLM scaling alone is insufficient. Demis Hassabis | AI | 49% |