Alpha plans to conduct a million-student pharmaceutical-grade randomized control trial on Timeback.
Predictor: Joe Liemandt · ep#233 "This $40M AI Company Is Using AI Tutors to Teach 2 Hours/Day | #233" · source
Prediction text
Alpha plans to conduct a million-student pharmaceutical-grade randomized control trial on Timeback. | one of the things that we'd love to do is be able to, you know, as we get all this data out there in this, you know, time back at scale is do a million student randomized control trial so that every pharmaceutical grade trial so everybody can be like, "This isn't a hoax, right? This this actually works."
Verbatim quote
one of the things that we'd love to do is be able to, you know, as we get all this data out there in this, you know, time back at scale is do a million student randomized control trial so that every pharmaceutical grade trial so everybody can be like, "This isn't a hoax, right? This this actually works."
Predictor: Joe Liemandt
Calibration plot (stated vs observed)
Evidence about this node from Joe Liemandt is multiplied by κ in /api/intake. Lower κ = less weight; floors at 0.10 (effectively silenced) and caps at 1.00 (full weight).
Reference class
This node isn't linked to a reference class. The Bayesian update applies without outside-view blending.
Probability over time
Milestone chain
- 2026-06-01 → 2027-12-31pendingAlpha School publicly announces formal RCT protocol with IRB approvalHow: Alpha School / Timeback / Trilogy publishes preregistered RCT protocol on ClinicalTrials.gov, OSF Registries, AEA RCT Registry, or equivalent — with IRB approval letterSource: deep_research_enrichedconf 45%
- 2026-09-01 → 2028-06-30pendingTimeback enrollment reaches 100K studentsHow: Alpha School / Timeback discloses or third-party verifies 100,000+ enrolled students using the Timeback platformSource: llm_enrichedconf 50%
- 2027-06-01 → 2029-12-31pendingFirst-stage RCT (10K-50K students) results publishedHow: Peer-reviewed or NBER working paper publishes outcomes of an Alpha-Timeback RCT with sample size >=10K studentsSource: llm_enrichedconf 40%
- 2028-01-01 → 2030-06-30pendingMillion-student RCT enrollment beginsHow: Alpha School / Timeback announces enrollment opening for an RCT with declared target sample size >=1,000,000 students — preregistered protocolSource: llm_enrichedconf 25%
- 2029-06-01 → 2031-12-31pendingMillion-student RCT primary endpoint readoutHow: Primary endpoint results of the million-student Timeback RCT published in peer-reviewed journal or top economics working paper venueSource: llm_enrichedconf 15%
What if this resolves?
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Evidence chain
Network propagation neighbors
Top incoming (parents)
Edges that influence THIS node's belief
| Kind | Node | Their prob | P(c|s=T) | P(c|s=F) | Δ implied |
|---|---|---|---|---|---|
| prereq | SEM_042 2025 will be the definitive year that agentic systems finall — Kevin Weil | 73.8% | 0.400 | 0.050 | -0.043 |
| prereq | 235_038 David Sinclair begins partial epigenetic reprogramming trial — Peter Diamandis | 74.0% | 0.400 | 0.050 | -0.042 |
| prereq | SEM_012 Nvidia quadrupled chip production output while only doubling — Jensen Huang | 75.0% | 0.400 | 0.050 | -0.038 |
| prereq | SEM_008 Training runs costing $10 billion for a single model will co — Dario Amodei | 76.9% | 0.400 | 0.050 | -0.032 |
| prereq | 238_009 Recursive self-improvement is already happening now (no long — Alex Wissner-Gross | 78.1% | 0.400 | 0.050 | -0.028 |
Top outgoing (children)
Predictions THIS node influences
| Kind | Node | Their prob | P(c|s=T) | P(c|s=F) | Δ implied |
|---|---|---|---|---|---|
| prereq | 235_030 Ray Kurzweil predicts Longevity Escape Velocity (LEV) by 203 — Ray Kurzweil | 39.2% | 0.750 | 0.050 | -0.104 |
| prereq | 246_016 Dragonfly nuclear-powered octicopter arrives at Titan in 203 — Peter Diamandis | 35.6% | 0.650 | 0.050 | -0.102 |
| prereq | 240_036 TEPCO's restarted reactor will support 20% of Japan's electr — Peter Diamandis | 34.3% | 0.650 | 0.050 | -0.089 |
| prereq | 239_008 Moon base will exist in 10 years — Elon Musk | 28.8% | 0.550 | 0.050 | -0.068 |
| prereq | SEM_034 True artificial general intelligence will be achieved betwee — Demis Hassabis | 28.7% | 0.550 | 0.050 | -0.067 |
Ticker exposure
Beneficiaries (23)
Adverse (6)
Prerequisites (8)
| Type | Pred | Title | Domain | Lag |
|---|---|---|---|---|
| prereq | 238_009 | Recursive self-improvement is already happening now (no longer three years out) | AI | — |
| prereq | 235_038 | David Sinclair begins partial epigenetic reprogramming trials with Life Biosciences in March 2026. | Biotech/Longevity | — |
| prereq | SEM_008 | Training runs costing $10 billion for a single model will commence sometime in 2025. | AI | — |
| prereq | SEM_012 | Nvidia quadrupled chip production output while only doubling human headcount — achieved by deploying AI coding tools (Cursor, Claude Code) across engineering. | AI/Manufacturing | — |
| prereq | SEM_042 | 2025 will be the definitive year that agentic systems finally hit the mainstream. | AI/Agents | — |
| killer | TK14 | Superbubble Pop (S&P 500 -40%, Moonshot Capital Evaporates) | — | — |
| killer | TK01 | AGI Capability Plateau (2026-27 Training Stall) | — | — |
| killer | TK03 | AI Regulatory Moratorium (EU/US Capability Freeze) | — | — |
Dependents (5)
| Type | Pred | Title | Domain | Lag |
|---|---|---|---|---|
| prereq | 235_030 | Ray Kurzweil predicts Longevity Escape Velocity (LEV) by 2033. | Biotech/Longevity | — |
| prereq | 246_016 | Dragonfly nuclear-powered octicopter arrives at Titan in 2034. | Space | — |
| prereq | 240_036 | TEPCO's restarted reactor will support 20% of Japan's electric needs by 2040 | Energy | — |
| prereq | SEM_034 | True artificial general intelligence will be achieved between 2032 and 2042 — 'first we solve AI, then use AI to solve everything else'. | AI/AGI | — |
| prereq | 239_008 | Moon base will exist in 10 years | Space | — |
Linked documents (10)
| Sim | Source | Title | Market prob | Polarity | Reviewed | Published |
|---|---|---|---|---|---|---|
| 0.609 | fda | FDA BLA761055: DUPIXENT (DUPILUMAB) — REGENERON PHARMACEUTICALS | — | mentions | pending | 2026-04-22 |
| 0.606 | arxiv | Adaptive Experimentation for Censored Survival Outcomes | — | mentions | pending | 2026-05-18 |
| 0.603 | fda | FDA NDA218197: TRUQAP (CAPIVASERTIB) — ASTRAZENECA | — | mentions | pending | 2026-05-27 |
| 0.602 | arxiv | DARTS: Targeting Prognostic Covariates in Budget-Constrained Sequential Experiments | — | mentions | pending | 2026-05-07 |
| 0.600 | fda | FDA NDA213756: KOSELUGO (SELUMETINIB SULFATE) — ASTRAZENECA | — | mentions | pending | 2026-05-26 |
| 0.598 | fda | FDA ANDA078257: ONDANSETRON HYDROCHLORIDE (ONDANSETRON HYDROCHLORIDE) — ONESOURCE SPECIALTY | — | mentions | pending | 2026-04-15 |
| 0.597 | fda | FDA ANDA201446: FALLBACK SOLO (LEVONORGESTREL) — LUPIN | — | mentions | pending | 2026-05-01 |
| 0.597 | fda | FDA NDA219943: KOSELUGO (SELUMETINIB) — ASTRAZENECA | — | mentions | pending | 2026-05-26 |
| 0.593 | fda | FDA ANDA079099: LAMOTRIGINE (LAMOTRIGINE) — GLENMARK PHARMS LTD | — | mentions | pending | 2026-04-17 |
| 0.592 | fda | FDA NDA217180: JAKAFI XR (RUXOLITINIB PHOSPHATE) — INCYTE CORPORATION | — | mentions | pending | 2026-05-01 |
Raw metadata
{
"nia": false,
"qty": "1 million students",
"url": "https://www.youtube.com/watch?v=X94eBT-VZnc",
"mode": "ASPIRATION",
"role": "Guest-CEO",
"caveats": "Aspirational rather than committed",
"context": "I would love, you know, one of the things that we'd love to do is be able to, you know, as we get all this data out there in this, you know, time back at scale is do a million student randomized control trial so that every pharmaceutical grade trial so everybody can be like, \"This isn't a hoax, right? This this actually works.\"",
"to_year": 2035,
"verbatim": "one of the things that we'd love to do is be able to, you know, as we get all this data out there in this, you know, time back at scale is do a million student randomized control trial so that every pharmaceutical grade trial so everybody can be like, \"This isn't a hoax, right? This this actually works.\"",
"conv_cues": "we'd love to do",
"direction": "HAPPEN",
"from_year": 2026,
"timeframe": "future (unspecified)",
"conv_level": "MEDIUM",
"milestones": [
{
"kind": "prereq",
"label": "Nvidia quadrupled chip production output while only doubling human headcount — achieved by deploying AI coding tools (Cursor, Claude Code) a",
"status": "hit",
"weight": 0.5,
"ordinal": -9,
"source_id": "SEM_012",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "prereq",
"label": "Training runs costing $10 billion for a single model will commence sometime in 2025.",
"status": "hit",
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"ordinal": -8,
"source_id": "SEM_008",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "prereq",
"label": "2025 will be the definitive year that agentic systems finally hit the mainstream.",
"status": "hit",
"weight": 0.5,
"ordinal": -7,
"source_id": "SEM_042",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "prereq",
"label": "Recursive self-improvement is already happening now (no longer three years out)",
"status": "hit",
"weight": 0.5,
"ordinal": -6,
"source_id": "238_009",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "prereq",
"label": "David Sinclair begins partial epigenetic reprogramming trials with Life Biosciences in March 2026.",
"status": "hit",
"weight": 0.5,
"ordinal": -5,
"source_id": "235_038",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "llm_pre_event",
"label": "Alpha School publicly announces formal RCT protocol with IRB approval",
"source": "deep_research_enriched",
"status": "pending",
"weight": 0.4,
"ordinal": -4,
"source_id": null,
"confidence": 0.45,
"source_url": "https://alpha.school/blog/introducing-timeback-the-next-evolution-of-alphas-model/",
"expected_date": "2027-03-17",
"research_origin": "training",
"expected_date_range": {
"to": "2027-12-31",
"from": "2026-06-01"
},
"measurement_criterion": "Alpha School / Timeback / Trilogy publishes preregistered RCT protocol on ClinicalTrials.gov, OSF Registries, AEA RCT Registry, or equivalent — with IRB approval letter"
},
{
"kind": "llm_pre_event",
"label": "Timeback enrollment reaches 100K students",
"source": "llm_enriched",
"status": "pending",
"weight": 0.4,
"ordinal": -3,
"source_id": null,
"confidence": 0.5,
"expected_date": "2027-08-01",
"research_origin": "training",
"expected_date_range": {
"to": "2028-06-30",
"from": "2026-09-01"
},
"measurement_criterion": "Alpha School / Timeback discloses or third-party verifies 100,000+ enrolled students using the Timeback platform"
... (truncated)