← Cockpit
242_047predictionBiotech/LongevityAI-timing

Frontier AI may solve most diseases in 5 years

Predictor: Alex Wissner-Gross · ep#242 "Elon Enters the Chip Race, the S&P 500 Repricing, and Human Drivers Will Become Illegal | EP #242" · source

Prior probability
45.0%
Current probability
38.7%
evolves via intake + LBP
Conviction
3/5
Signal quality
C
Resolution
pending
Window
2031-01-01 – 2031-11-30
Edges in / out
10 / 5
Tickers exposed
33

Prediction text

Frontier AI may solve most diseases in 5 years | when do I think AI has a decent chance of solving most diseases? My timeline... I think they'll say something like five years from now

Verbatim quote

From episode "Elon Enters the Chip Race, the S&P 500 Repricing, and Human Drivers Will Become Illegal | EP #242"
when do I think AI has a decent chance of solving most diseases? My timeline... I think they'll say something like five years from now

Predictor: Alex Wissner-Gross

κ + Brier as of 2026-05-22
κ (discount)
0.844
Brier
0.0341
excellent
Hits / Misses
6 / 1
of 11 resolved
Hit rate
54.5%
Calibration plot (stated vs observed)

Evidence about this node from Alex Wissner-Gross is multiplied by κ in /api/intake. Lower κ = less weight; floors at 0.10 (effectively silenced) and caps at 1.00 (full weight).

Reference class

Not linked

This node isn't linked to a reference class. The Bayesian update applies without outside-view blending.

Probability over time

3 prob_history rows
0%25%50%75%100%prior 45%2026-04-302026-04-302026-05-03
intake v2milestone miss sweeplbp propagationreference class assignedlegacy v1prior_prob (analyst seed)current = 38.7%

Milestone chain

Pre-event signals (upstream prereqs + window checkpoints) → resolution event → downstream cascades. Status/dates update from linked nodes; re-derive nightly via scripts/ops/derive_milestones.py.
Leading chain: 5 fired ✓ · 5 pending
  1. 2026-01-22hitDeepMind/Isomorphic Labs first AI-designed cancer drug enters Phase 1 clinical trials
    How: Isomorphic Labs lead oncology candidate begins Phase 1 dosing per Hassabis WEF announcement
    Source: deep_research_enrichedconf 92%
  2. 2026-06-01 → 2027-06-30pendingIsomorphic Labs pipeline expands to 17+ active programs with Eli Lilly and Novartis partnerships in mid-trials
    How: Isomorphic discloses 17+ active programs, multiple partner-pharma compounds in Phase 2
    Source: deep_research_enrichedconf 70%
  3. 2028-06-01 → 2030-12-31pendingFirst AI-designed drug receives FDA approval (any indication, primary structure designed by frontier model)
    How: FDA approval letter for product where lead structure originated from frontier-AI design pipeline
    Source: deep_research_enrichedconf 50%
  4. 2029-01-01 → 2031-06-30pendingFirst 'virtual cell' (full molecular-state predictive simulation) demonstrated for clinical-grade intervention modeling
    How: DeepMind/Isomorphic publish virtual cell platform validated against clinical drug-response data for at least one disease
    Source: deep_research_enrichedconf 40%
  5. 2030-06-01 → 2031-12-31pendingCumulative AI-designed drug approvals reach 10+ across major disease categories
    How: FDA tracking shows 10+ approved drugs whose lead structures originated from frontier-AI design
    Source: deep_research_enrichedconf 30%
  6. 2036-09-06pendingMoon base will exist in 10 years

What if this resolves?

Clamp this prediction TRUE or FALSE and run a counterfactual Gibbs sample. Surfaces the predictions whose marginals shift most under that assumption.
(live posterior: 39%)

Click a button to clamp this prediction and run a Gibbs sample. Returns the predictions whose marginals shift most. ~30s per run; ideal for stress-testing "if X resolves, what else moves?"

Evidence chain

Every probability update with full Bayesian provenance — chronological, latest first
LBP2026-05-03T02:00:01Z38.7%-1.4pp
Network propagation: 40.0% → 38.7%
6-iter LBP, residual 0.00677 · damping 0.5, w_intrinsic 0.5 · method lbp_v3 · run 1a683ac9
LBP2026-04-30T16:39:51Z40.0%-2.0pp
Network propagation: 42.0% → 40.0%
5-iter LBP, residual 0.00825 · damping 0.5, w_intrinsic 0.5 · method lbp_v2 · run 0c8a4ea3
LBP2026-04-30T02:18:57Z42.0%-3.0pp
Network propagation: 45.0% → 42.0%
5-iter LBP, residual 0.00825 · damping 0.5, w_intrinsic 0.5 · method lbp_v1 · run 592311ef

Network propagation neighbors

Top edges sorted by latest LBP cross-impact
All propagation →

Top incoming (parents)

Edges that influence THIS node's belief

KindNodeTheir probP(c|s=T)P(c|s=F)Δ implied
prereq234_012
Anthropic revenue will cross OpenAI revenue in middle of 202Peter Diamandis
67.1%0.4500.050-0.071
prereqSEM_005
Stargate is a $500 billion multiyear capex program for distrSam Altman
72.3%0.4500.050-0.068
prereq235_002
Anthropic will exceed OpenAI in revenue this year (2026).Dave Blundin
74.6%0.4500.050-0.042
prereqSEM_012
Nvidia quadrupled chip production output while only doublingJensen Huang
75.0%0.4500.050-0.040
prereqSEM_008
Training runs costing $10 billion for a single model will coDario Amodei
76.9%0.4500.050-0.032

Top outgoing (children)

Predictions THIS node influences

KindNodeTheir probP(c|s=T)P(c|s=F)Δ implied
prereq246_016
Dragonfly nuclear-powered octicopter arrives at Titan in 203Peter Diamandis
35.6%0.6500.050-0.079
prereq235_030
Ray Kurzweil predicts Longevity Escape Velocity (LEV) by 203Ray Kurzweil
39.2%0.7500.050-0.078
prereq240_036
TEPCO's restarted reactor will support 20% of Japan's electrPeter Diamandis
34.3%0.6500.050-0.066
prereq239_008
Moon base will exist in 10 yearsElon Musk
28.8%0.5500.050-0.049
prereqSEM_034
True artificial general intelligence will be achieved betweeDemis Hassabis
28.7%0.5500.050-0.048

Ticker exposure

33 ticker(s) linked

Beneficiaries (23)

SOUNCRWVSITMNVDAARMGTLBBBAITSMAPLDCEVAAIMSFTMRVLSFTBYORCLQCOMAVGOBABAAMDGOOGLIBMAMZNMETA

Adverse (6)

WNSCHGGCTSHIBMINFYACN

Prerequisites (10)

Predictions that must hit first
TypePredTitleDomainLag
prereq234_012Anthropic revenue will cross OpenAI revenue in middle of 2026Markets/Stocks
prereq235_002Anthropic will exceed OpenAI in revenue this year (2026).AI
prereqSEM_008Training runs costing $10 billion for a single model will commence sometime in 2025.AI
prereqSEM_012Nvidia quadrupled chip production output while only doubling human headcount — achieved by deploying AI coding tools (Cursor, Claude Code) across engineering.AI/Manufacturing
prereqSEM_005Stargate is a $500 billion multiyear capex program for distributed AI data-center construction (2025-2028, with Trump administration partnership).AI/Infrastructure
correlateS_AGI_SLOW_2031AGI slow: Schmidt/Hassabis 5-10 year pathagi_general_capability
correlateS_AGI_WINTER_2036PLUSAGI delayed: capability plateau or AI winteragi_general_capability
killerTK14Superbubble Pop (S&P 500 -40%, Moonshot Capital Evaporates)
killerTK01AGI Capability Plateau (2026-27 Training Stall)
killerTK03AI Regulatory Moratorium (EU/US Capability Freeze)

Dependents (5)

Predictions enabled by this
TypePredTitleDomainLag
prereq235_030Ray Kurzweil predicts Longevity Escape Velocity (LEV) by 2033.Biotech/Longevity
prereq246_016Dragonfly nuclear-powered octicopter arrives at Titan in 2034.Space
prereq240_036TEPCO's restarted reactor will support 20% of Japan's electric needs by 2040Energy
prereqSEM_034True artificial general intelligence will be achieved between 2032 and 2042 — 'first we solve AI, then use AI to solve everything else'.AI/AGI
prereq239_008Moon base will exist in 10 yearsSpace

Linked documents (7)

Auto-generated by cosine similarity from Polymarket / Manifold / EDGAR / GDELT
SimSourceTitleMarket probPolarityReviewedPublished
0.697manifoldWhich Epoch AI FrontierMath open problem will be solved next?mentionspending2026-04-23
0.593manifoldWill a vaccine against the Andes virus (hantavirus) be tested in humans before the end of 2027?34%mentionspending2026-05-07
0.590manifoldWill the top HN story have 500+ points when this resolves?74%mentionspending2026-05-10
0.585manifoldWill an Average New Zealander born in the year 2000 live to 150? (RESOLVES IN A WEEK)38%mentionspending2026-06-03
0.572polymarketConfirmed case of Hantavirus in US by May 15?12%mentionspending2026-05-04
0.572manifoldHantavirus Pandemic 2026-2027?6%mentionspending2026-05-07
0.556manifoldWill I get COVID ten times before getting hantavirus?27%mentionspending2026-05-16

Raw metadata

From Thesis_Timeline_v1.0_FINAL workbook
{
  "nia": false,
  "qty": "top 5,000 diseases",
  "url": "https://www.youtube.com/watch?v=wMLcIWLlcWg",
  "mode": "FORECAST",
  "role": "Host",
  "context": "AI has a decent chance of solving most diseases? My timeline... something like five years from now",
  "to_year": 2031,
  "verbatim": "when do I think AI has a decent chance of solving most diseases? My timeline... I think they'll say something like five years from now",
  "conv_cues": "decent chance",
  "direction": "HAPPEN",
  "from_year": 2031,
  "timeframe": "5 years",
  "conv_level": "MEDIUM",
  "milestones": [
    {
      "kind": "llm_pre_event",
      "label": "DeepMind/Isomorphic Labs first AI-designed cancer drug enters Phase 1 clinical trials",
      "source": "deep_research_enriched",
      "status": "hit",
      "weight": 0.4,
      "ordinal": -10,
      "source_id": null,
      "confidence": 0.92,
      "source_url": "https://creati.ai/ai-news/2026-02-14/deepmind-ai-cancer-drug-clinical-trials-2026-demis-hassabis/",
      "expected_date": "2026-01-22",
      "observed_date": "2026-01-22",
      "research_origin": "deep_research",
      "measurement_criterion": "Isomorphic Labs lead oncology candidate begins Phase 1 dosing per Hassabis WEF announcement"
    },
    {
      "kind": "prereq",
      "label": "Nvidia quadrupled chip production output while only doubling human headcount — achieved by deploying AI coding tools (Cursor, Claude Code) a",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -9,
      "source_id": "SEM_012",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Training runs costing $10 billion for a single model will commence sometime in 2025.",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -8,
      "source_id": "SEM_008",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Anthropic revenue will cross OpenAI revenue in middle of 2026",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -7,
      "source_id": "234_012",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Anthropic will exceed OpenAI in revenue this year (2026).",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -6,
      "source_id": "235_002",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "llm_pre_event",
      "label": "Isomorphic Labs pipeline expands to 17+ active programs with Eli Lilly and Novartis partnerships in mid-trials",
      "source": "deep_research_enriched",
      "status": "pending",
      "weight": 0.4,
      "ordinal": -5,
      "source_id": null,
      "confidence": 0.7,
      "source_url": "https://www.isomorphiclabs.com/",
      "expected_date": "2026-12-15",
      "research_origin": "deep_research",
      "expected_date_range": {
        "to": "2027-06-30",
        "from": "2026-06-01"
      },
      "measurement_criterion": "Isomorphic discloses 17+ active programs, multiple partner-pharma compounds in Phase 2"
    },
    {
      "kind": "prereq",
      "label": "Stargate is a $500 billion multiyear capex program for distributed AI data-center construction (2025-2028, with Trump administration partner",
      "status": "pending",
      "weight": 0.5,
      "ordinal": -4,
      "source_id": "SEM_005",
      "expected_date": "2028-02-09",
      "observed_date": null
    },
    {
      "kind": "llm_pre_event",
      "label": "First AI-designed drug receives FDA approval (any indication, primary structure designed by frontier model)",
      "source": "deep_research_enriched",
      "status": "pending",
      "weight": 0.4,
      "ordinal": -3,
      "source_id": null,
      "confidence": 0.5,
      "source_url": "https://fortune.com/article/demis-hassabis-deepmind-artificial-intelligence-google-alphabet-drug-discovery-isomorphic/",
   
... (truncated)