← Cockpit
232_039predictionBiotech/LongevityAI-timing

150,000 people per day dying on Earth; AI is the best chance to stop that.

Predictor: Alex Wissner-Gross · ep#232 "Ben Horowitz: xAI Executive Exodus, Apple's AI Crisis, The Pace of AI | EP #232" · source

Prior probability
50.0%
Current probability
41.6%
evolves via intake + LBP
Conviction
4/5
Signal quality
B
Resolution
pending
Window
2033-06-01 – 2033-06-30
Edges in / out
8 / 5
Tickers exposed
33

Prediction text

150,000 people per day dying on Earth; AI is the best chance to stop that. | I I think we have 150,000 people per day dying on Earth. And I think AI is probably the best chance we have at stopping that.

Verbatim quote

From episode "Ben Horowitz: xAI Executive Exodus, Apple's AI Crisis, The Pace of AI | EP #232"
I I think we have 150,000 people per day dying on Earth. And I think AI is probably the best chance we have at stopping that.

Predictor: Alex Wissner-Gross

κ + Brier as of 2026-05-22
κ (discount)
0.844
Brier
0.0341
excellent
Hits / Misses
6 / 1
of 11 resolved
Hit rate
54.5%
Calibration plot (stated vs observed)

Evidence about this node from Alex Wissner-Gross is multiplied by κ in /api/intake. Lower κ = less weight; floors at 0.10 (effectively silenced) and caps at 1.00 (full weight).

Reference class

Not linked

This node isn't linked to a reference class. The Bayesian update applies without outside-view blending.

Probability over time

4 prob_history rows
0%25%50%75%100%prior 50%2026-04-302026-05-032026-05-10
intake v2milestone miss sweeplbp propagationreference class assignedlegacy v1prior_prob (analyst seed)current = 41.6%

Milestone chain

Pre-event signals (upstream prereqs + window checkpoints) → resolution event → downstream cascades. Status/dates update from linked nodes; re-derive nightly via scripts/ops/derive_milestones.py.
Leading chain: 6 fired ✓ · 4 pending
  1. 2026-02-28hitFirst fully AI-designed drug completes Phase IIa with efficacy
    How: Drug fully designed by AI from target identification through optimization completes Phase IIa clinical trial with statistically significant efficacy reported
    Source: Insilico Medicine — INS018_055 for IPF, designed and optimized by AI in 18 months at ~$6M cost vs $100-200M traditionalconf 99%
    Notes: HIT — Insilico INS018_055 announced Feb 2026 with significant Phase IIa efficacy.
  2. 2026-03-31hitAlphaFold-derived AI cancer drug enters Phase 1
    How: DeepMind/Isomorphic Labs or similar AlphaFold-pipeline cancer drug begins enrollment for Phase 1 clinical trial
    Source: Demis Hassabis Davos 2026 confirmation of first AI-designed cancer drug entering Phase 1; Isomorphic Labs IsoDDE technical report Feb 2026conf 95%
  3. 2027-01-01 → 2030-12-31pendingAI healthcare reduces all-cause mortality in any large-scale deployment
    How: Peer-reviewed study with N>100,000 patient cohort shows all-cause mortality reduction >10% attributable to AI clinical decision support / diagnostics deployment
    Source: EIT Health AI tool reduced COVID-19 hospital mortality by 50%; PMC 2026 healthcare predictions on AI reducing mortalityconf 55%
  4. 2027-01-01 → 2031-12-31pendingAI sudden-cardiac-death detection deployed at population scale
    How: AI ECG/wearable system identifying high-SCD-risk individuals deployed across >1M-person cohort with peer-reviewed validation of >25% reduction in unmonitored sudden cardiac deaths
    Source: PMC 2026 — AI identifies people at ~90% sudden-death risk accounting for 25% of all sudden cardiac deathsconf 50%
  5. 2030-01-01 → 2033-06-30pendingGlobal daily mortality decreases despite population growth
    How: WHO Global Health Estimates report global crude death count below 150,000/day for any sustained 12-month window despite population growth, with academic consensus citing AI healthcare contribution
    Source: WHO Global Health Estimates baseline; SOA 2025 'Impact of AI on Human Longevity' analysisconf 20%
    Notes: Cascade — direct test of '150,000 dying per day, AI is best chance to stop that'.
  6. 2036-08-14pendingPeople will be on Mars within 10 years
  7. 2036-09-06pendingMoon base will exist in 10 years

What if this resolves?

Clamp this prediction TRUE or FALSE and run a counterfactual Gibbs sample. Surfaces the predictions whose marginals shift most under that assumption.
(live posterior: 42%)

Click a button to clamp this prediction and run a Gibbs sample. Returns the predictions whose marginals shift most. ~30s per run; ideal for stress-testing "if X resolves, what else moves?"

Evidence chain

Every probability update with full Bayesian provenance — chronological, latest first
LBP2026-05-10T02:00:02Z41.6%-1.1pp
Network propagation: 42.7% → 41.6%
6-iter LBP, residual 0.00584 · damping 0.5, w_intrinsic 0.5 · method lbp_v3 · run e5c18d29
LBP2026-05-03T02:00:01Z42.7%-1.7pp
Network propagation: 44.4% → 42.7%
6-iter LBP, residual 0.00677 · damping 0.5, w_intrinsic 0.5 · method lbp_v3 · run 1a683ac9
LBP2026-04-30T16:39:51Z44.4%-2.2pp
Network propagation: 46.6% → 44.4%
5-iter LBP, residual 0.00825 · damping 0.5, w_intrinsic 0.5 · method lbp_v2 · run 0c8a4ea3
LBP2026-04-30T02:18:57Z46.6%-3.4pp
Network propagation: 50.0% → 46.6%
5-iter LBP, residual 0.00825 · damping 0.5, w_intrinsic 0.5 · method lbp_v1 · run 592311ef

Network propagation neighbors

Top edges sorted by latest LBP cross-impact
All propagation →

Top incoming (parents)

Edges that influence THIS node's belief

KindNodeTheir probP(c|s=T)P(c|s=F)Δ implied
prereq234_012
Anthropic revenue will cross OpenAI revenue in middle of 202Peter Diamandis
67.1%0.5000.050-0.067
prereqSEM_005
Stargate is a $500 billion multiyear capex program for distrSam Altman
72.3%0.5000.050-0.065
killerTK03
AI Regulatory Moratorium (EU/US Capability Freeze)
10.0%0.0500.500+0.039
prereq235_002
Anthropic will exceed OpenAI in revenue this year (2026).Dave Blundin
74.6%0.5000.050-0.035
prereqSEM_012
Nvidia quadrupled chip production output while only doublingJensen Huang
75.0%0.5000.050-0.032

Top outgoing (children)

Predictions THIS node influences

KindNodeTheir probP(c|s=T)P(c|s=F)Δ implied
prereq246_016
Dragonfly nuclear-powered octicopter arrives at Titan in 203Peter Diamandis
35.6%0.6500.050-0.060
prereq239_009
People will be on Mars within 10 yearsElon Musk
30.9%0.5500.050-0.054
prereq240_036
TEPCO's restarted reactor will support 20% of Japan's electrPeter Diamandis
34.3%0.6500.050-0.046
prereq232_047
Mass drivers on the moon will shoot AI satellites into deep Elon Musk
30.0%0.5500.050-0.044
prereq239_008
Moon base will exist in 10 yearsElon Musk
28.8%0.5500.050-0.033

Ticker exposure

33 ticker(s) linked

Beneficiaries (23)

SOUNCRWVSITMNVDAARMGTLBBBAITSMAPLDCEVAAIMSFTMRVLSFTBYORCLQCOMAVGOBABAAMDGOOGLIBMAMZNMETA

Adverse (6)

WNSCHGGCTSHIBMINFYACN

Prerequisites (8)

Predictions that must hit first
TypePredTitleDomainLag
prereq234_012Anthropic revenue will cross OpenAI revenue in middle of 2026Markets/Stocks
prereq235_002Anthropic will exceed OpenAI in revenue this year (2026).AI
prereqSEM_008Training runs costing $10 billion for a single model will commence sometime in 2025.AI
prereqSEM_012Nvidia quadrupled chip production output while only doubling human headcount — achieved by deploying AI coding tools (Cursor, Claude Code) across engineering.AI/Manufacturing
prereqSEM_005Stargate is a $500 billion multiyear capex program for distributed AI data-center construction (2025-2028, with Trump administration partnership).AI/Infrastructure
killerTK14Superbubble Pop (S&P 500 -40%, Moonshot Capital Evaporates)
killerTK01AGI Capability Plateau (2026-27 Training Stall)
killerTK03AI Regulatory Moratorium (EU/US Capability Freeze)

Dependents (5)

Predictions enabled by this
TypePredTitleDomainLag
prereq246_016Dragonfly nuclear-powered octicopter arrives at Titan in 2034.Space
prereq240_036TEPCO's restarted reactor will support 20% of Japan's electric needs by 2040Energy
prereq239_008Moon base will exist in 10 yearsSpace
prereq239_009People will be on Mars within 10 yearsSpace
prereq232_047Mass drivers on the moon will shoot AI satellites into deep space; self-sustaining lunar city will follow.Space

Raw metadata

From Thesis_Timeline_v1.0_FINAL workbook
{
  "nia": false,
  "url": "https://www.youtube.com/watch?v=C1GLT9_tag0",
  "mode": "THESIS",
  "role": "Host",
  "context": "I I think we have 150,000 people per day dying on Earth. And I think AI is probably the best chance we have at stopping that. I I think Nick Bostonramm, who also in the past 24 or 48 hours put out a a wonderful essay that I'd recommend everyone read called Optimal Timing for Super Intelligence, argues that AI can and should be paused, but only once we're on the verge of super intelligence.",
  "to_year": 2040,
  "verbatim": "I I think we have 150,000 people per day dying on Earth. And I think AI is probably the best chance we have at stopping that.",
  "conv_cues": "probably the best chance",
  "direction": "HAPPEN",
  "from_year": 2026,
  "timeframe": "unspecified",
  "conv_level": "HIGH",
  "milestones": [
    {
      "kind": "llm_pre_event",
      "label": "First fully AI-designed drug completes Phase IIa with efficacy",
      "notes": "HIT — Insilico INS018_055 announced Feb 2026 with significant Phase IIa efficacy.",
      "source": "Insilico Medicine — INS018_055 for IPF, designed and optimized by AI in 18 months at ~$6M cost vs $100-200M traditional",
      "status": "hit",
      "weight": 0.4,
      "ordinal": -10,
      "source_id": null,
      "confidence": 0.99,
      "source_url": "https://www.aimagicx.com/blog/ai-drug-discovery-pharma-cost-disruption-2026",
      "expected_date": "2026-02-28",
      "observed_date": "2026-02-28",
      "research_origin": "deep_research",
      "measurement_criterion": "Drug fully designed by AI from target identification through optimization completes Phase IIa clinical trial with statistically significant efficacy reported"
    },
    {
      "kind": "llm_pre_event",
      "label": "AlphaFold-derived AI cancer drug enters Phase 1",
      "source": "Demis Hassabis Davos 2026 confirmation of first AI-designed cancer drug entering Phase 1; Isomorphic Labs IsoDDE technical report Feb 2026",
      "status": "hit",
      "weight": 0.4,
      "ordinal": -9,
      "source_id": null,
      "confidence": 0.95,
      "source_url": "https://creati.ai/ai-news/2026-02-14/deepmind-ai-cancer-drug-clinical-trials-2026-demis-hassabis/",
      "expected_date": "2026-03-31",
      "observed_date": "2026-03-31",
      "research_origin": "deep_research",
      "measurement_criterion": "DeepMind/Isomorphic Labs or similar AlphaFold-pipeline cancer drug begins enrollment for Phase 1 clinical trial"
    },
    {
      "kind": "prereq",
      "label": "Nvidia quadrupled chip production output while only doubling human headcount — achieved by deploying AI coding tools (Cursor, Claude Code) a",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -8,
      "source_id": "SEM_012",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Training runs costing $10 billion for a single model will commence sometime in 2025.",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -7,
      "source_id": "SEM_008",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Anthropic revenue will cross OpenAI revenue in middle of 2026",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -6,
      "source_id": "234_012",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Anthropic will exceed OpenAI in revenue this year (2026).",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -5,
      "source_id": "235_002",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Stargate is a $500 billion multiyear capex program for distributed AI data-center construction (2025-2028, with Trump administration partner",
      "status": "pending",
      "weight": 0.5,
      "ordinal": -4,
      "
... (truncated)