150,000 people per day dying on Earth; AI is the best chance to stop that.
Predictor: Alex Wissner-Gross · ep#232 "Ben Horowitz: xAI Executive Exodus, Apple's AI Crisis, The Pace of AI | EP #232" · source
Prediction text
150,000 people per day dying on Earth; AI is the best chance to stop that. | I I think we have 150,000 people per day dying on Earth. And I think AI is probably the best chance we have at stopping that.
Verbatim quote
I I think we have 150,000 people per day dying on Earth. And I think AI is probably the best chance we have at stopping that.
Predictor: Alex Wissner-Gross
Calibration plot (stated vs observed)
Evidence about this node from Alex Wissner-Gross is multiplied by κ in /api/intake. Lower κ = less weight; floors at 0.10 (effectively silenced) and caps at 1.00 (full weight).
Reference class
This node isn't linked to a reference class. The Bayesian update applies without outside-view blending.
Probability over time
Milestone chain
- 2026-02-28hitFirst fully AI-designed drug completes Phase IIa with efficacyHow: Drug fully designed by AI from target identification through optimization completes Phase IIa clinical trial with statistically significant efficacy reportedSource: Insilico Medicine — INS018_055 for IPF, designed and optimized by AI in 18 months at ~$6M cost vs $100-200M traditionalconf 99%Notes: HIT — Insilico INS018_055 announced Feb 2026 with significant Phase IIa efficacy.
- 2026-03-31hitAlphaFold-derived AI cancer drug enters Phase 1How: DeepMind/Isomorphic Labs or similar AlphaFold-pipeline cancer drug begins enrollment for Phase 1 clinical trialSource: Demis Hassabis Davos 2026 confirmation of first AI-designed cancer drug entering Phase 1; Isomorphic Labs IsoDDE technical report Feb 2026conf 95%
- 2027-01-01 → 2030-12-31pendingAI healthcare reduces all-cause mortality in any large-scale deploymentHow: Peer-reviewed study with N>100,000 patient cohort shows all-cause mortality reduction >10% attributable to AI clinical decision support / diagnostics deploymentSource: EIT Health AI tool reduced COVID-19 hospital mortality by 50%; PMC 2026 healthcare predictions on AI reducing mortalityconf 55%
- 2027-01-01 → 2031-12-31pendingAI sudden-cardiac-death detection deployed at population scaleHow: AI ECG/wearable system identifying high-SCD-risk individuals deployed across >1M-person cohort with peer-reviewed validation of >25% reduction in unmonitored sudden cardiac deathsSource: PMC 2026 — AI identifies people at ~90% sudden-death risk accounting for 25% of all sudden cardiac deathsconf 50%
- 2030-01-01 → 2033-06-30pendingGlobal daily mortality decreases despite population growthHow: WHO Global Health Estimates report global crude death count below 150,000/day for any sustained 12-month window despite population growth, with academic consensus citing AI healthcare contributionSource: WHO Global Health Estimates baseline; SOA 2025 'Impact of AI on Human Longevity' analysisconf 20%Notes: Cascade — direct test of '150,000 dying per day, AI is best chance to stop that'.
What if this resolves?
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Evidence chain
Network propagation neighbors
Top incoming (parents)
Edges that influence THIS node's belief
| Kind | Node | Their prob | P(c|s=T) | P(c|s=F) | Δ implied |
|---|---|---|---|---|---|
| prereq | 234_012 Anthropic revenue will cross OpenAI revenue in middle of 202 — Peter Diamandis | 67.1% | 0.500 | 0.050 | -0.067 |
| prereq | SEM_005 Stargate is a $500 billion multiyear capex program for distr — Sam Altman | 72.3% | 0.500 | 0.050 | -0.065 |
| killer | TK03 AI Regulatory Moratorium (EU/US Capability Freeze) | 10.0% | 0.050 | 0.500 | +0.039 |
| prereq | 235_002 Anthropic will exceed OpenAI in revenue this year (2026). — Dave Blundin | 74.6% | 0.500 | 0.050 | -0.035 |
| prereq | SEM_012 Nvidia quadrupled chip production output while only doubling — Jensen Huang | 75.0% | 0.500 | 0.050 | -0.032 |
Top outgoing (children)
Predictions THIS node influences
| Kind | Node | Their prob | P(c|s=T) | P(c|s=F) | Δ implied |
|---|---|---|---|---|---|
| prereq | 246_016 Dragonfly nuclear-powered octicopter arrives at Titan in 203 — Peter Diamandis | 35.6% | 0.650 | 0.050 | -0.060 |
| prereq | 239_009 People will be on Mars within 10 years — Elon Musk | 30.9% | 0.550 | 0.050 | -0.054 |
| prereq | 240_036 TEPCO's restarted reactor will support 20% of Japan's electr — Peter Diamandis | 34.3% | 0.650 | 0.050 | -0.046 |
| prereq | 232_047 Mass drivers on the moon will shoot AI satellites into deep — Elon Musk | 30.0% | 0.550 | 0.050 | -0.044 |
| prereq | 239_008 Moon base will exist in 10 years — Elon Musk | 28.8% | 0.550 | 0.050 | -0.033 |
Ticker exposure
Beneficiaries (23)
Adverse (6)
Prerequisites (8)
| Type | Pred | Title | Domain | Lag |
|---|---|---|---|---|
| prereq | 234_012 | Anthropic revenue will cross OpenAI revenue in middle of 2026 | Markets/Stocks | — |
| prereq | 235_002 | Anthropic will exceed OpenAI in revenue this year (2026). | AI | — |
| prereq | SEM_008 | Training runs costing $10 billion for a single model will commence sometime in 2025. | AI | — |
| prereq | SEM_012 | Nvidia quadrupled chip production output while only doubling human headcount — achieved by deploying AI coding tools (Cursor, Claude Code) across engineering. | AI/Manufacturing | — |
| prereq | SEM_005 | Stargate is a $500 billion multiyear capex program for distributed AI data-center construction (2025-2028, with Trump administration partnership). | AI/Infrastructure | — |
| killer | TK14 | Superbubble Pop (S&P 500 -40%, Moonshot Capital Evaporates) | — | — |
| killer | TK01 | AGI Capability Plateau (2026-27 Training Stall) | — | — |
| killer | TK03 | AI Regulatory Moratorium (EU/US Capability Freeze) | — | — |
Dependents (5)
| Type | Pred | Title | Domain | Lag |
|---|---|---|---|---|
| prereq | 246_016 | Dragonfly nuclear-powered octicopter arrives at Titan in 2034. | Space | — |
| prereq | 240_036 | TEPCO's restarted reactor will support 20% of Japan's electric needs by 2040 | Energy | — |
| prereq | 239_008 | Moon base will exist in 10 years | Space | — |
| prereq | 239_009 | People will be on Mars within 10 years | Space | — |
| prereq | 232_047 | Mass drivers on the moon will shoot AI satellites into deep space; self-sustaining lunar city will follow. | Space | — |
Raw metadata
{
"nia": false,
"url": "https://www.youtube.com/watch?v=C1GLT9_tag0",
"mode": "THESIS",
"role": "Host",
"context": "I I think we have 150,000 people per day dying on Earth. And I think AI is probably the best chance we have at stopping that. I I think Nick Bostonramm, who also in the past 24 or 48 hours put out a a wonderful essay that I'd recommend everyone read called Optimal Timing for Super Intelligence, argues that AI can and should be paused, but only once we're on the verge of super intelligence.",
"to_year": 2040,
"verbatim": "I I think we have 150,000 people per day dying on Earth. And I think AI is probably the best chance we have at stopping that.",
"conv_cues": "probably the best chance",
"direction": "HAPPEN",
"from_year": 2026,
"timeframe": "unspecified",
"conv_level": "HIGH",
"milestones": [
{
"kind": "llm_pre_event",
"label": "First fully AI-designed drug completes Phase IIa with efficacy",
"notes": "HIT — Insilico INS018_055 announced Feb 2026 with significant Phase IIa efficacy.",
"source": "Insilico Medicine — INS018_055 for IPF, designed and optimized by AI in 18 months at ~$6M cost vs $100-200M traditional",
"status": "hit",
"weight": 0.4,
"ordinal": -10,
"source_id": null,
"confidence": 0.99,
"source_url": "https://www.aimagicx.com/blog/ai-drug-discovery-pharma-cost-disruption-2026",
"expected_date": "2026-02-28",
"observed_date": "2026-02-28",
"research_origin": "deep_research",
"measurement_criterion": "Drug fully designed by AI from target identification through optimization completes Phase IIa clinical trial with statistically significant efficacy reported"
},
{
"kind": "llm_pre_event",
"label": "AlphaFold-derived AI cancer drug enters Phase 1",
"source": "Demis Hassabis Davos 2026 confirmation of first AI-designed cancer drug entering Phase 1; Isomorphic Labs IsoDDE technical report Feb 2026",
"status": "hit",
"weight": 0.4,
"ordinal": -9,
"source_id": null,
"confidence": 0.95,
"source_url": "https://creati.ai/ai-news/2026-02-14/deepmind-ai-cancer-drug-clinical-trials-2026-demis-hassabis/",
"expected_date": "2026-03-31",
"observed_date": "2026-03-31",
"research_origin": "deep_research",
"measurement_criterion": "DeepMind/Isomorphic Labs or similar AlphaFold-pipeline cancer drug begins enrollment for Phase 1 clinical trial"
},
{
"kind": "prereq",
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"status": "hit",
"weight": 0.5,
"ordinal": -8,
"source_id": "SEM_012",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "prereq",
"label": "Training runs costing $10 billion for a single model will commence sometime in 2025.",
"status": "hit",
"weight": 0.5,
"ordinal": -7,
"source_id": "SEM_008",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "prereq",
"label": "Anthropic revenue will cross OpenAI revenue in middle of 2026",
"status": "hit",
"weight": 0.5,
"ordinal": -6,
"source_id": "234_012",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "prereq",
"label": "Anthropic will exceed OpenAI in revenue this year (2026).",
"status": "hit",
"weight": 0.5,
"ordinal": -5,
"source_id": "235_002",
"expected_date": "2026-04-29",
"observed_date": "2026-04-29"
},
{
"kind": "prereq",
"label": "Stargate is a $500 billion multiyear capex program for distributed AI data-center construction (2025-2028, with Trump administration partner",
"status": "pending",
"weight": 0.5,
"ordinal": -4,
"
... (truncated)