Every single discipline (math, physics, chemistry, medicine) will be flattened by well-targeted generalist AIs.

Every single discipline (math, physics, chemistry, medicine) will be flattened by well-targeted generalist AIs. | Peter and I just wrote uh call it a book, call it an extended essay called Solve Everything, solve everything.org. ... Where we argue that every single discipline, math, physics, chemistry, medicine, bunch of other disciplines are just going to get flattened, steamrolled by welltargeted generalist AIs. And in my mind, materials research, biology in in the previous slide, these are just case studies. Everything is going to start to look like Alpha Fold 3 where structural biology got solved overnight

Peter and I just wrote uh call it a book, call it an extended essay called Solve Everything, solve everything.org. ... Where we argue that every single discipline, math, physics, chemistry, medicine, bunch of other disciplines are just going to get flattened, steamrolled by welltargeted generalist AIs. And in my mind, materials research, biology in in the previous slide, these are just case studies. Everything is going to start to look like Alpha Fold 3 where structural biology got solved overnight

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{
  "nia": false,
  "url": "https://www.youtube.com/watch?v=C1GLT9_tag0",
  "mode": "THESIS",
  "role": "Host",
  "context": "Where we argue that every single discipline, math, physics, chemistry, medicine, bunch of other disciplines are just going to get flattened, steamrolled by welltargeted generalist AIs. And in my mind, materials research, biology in in the previous slide, these are just case studies. Everything is going to start to look like Alpha Fold 3 where structural biology got solved overnight in including medicine.",
  "to_year": 2030,
  "verbatim": "Peter and I just wrote uh call it a book, call it an extended essay called Solve Everything, solve everything.org. ... Where we argue that every single discipline, math, physics, chemistry, medicine, bunch of other disciplines are just going to get flattened, steamrolled by welltargeted generalist AIs. And in my mind, materials research, biology in in the previous slide, these are just case studies. Everything is going to start to look like Alpha Fold 3 where structural biology got solved overnight",
  "conv_cues": "going to get flattened, steamrolled",
  "direction": "HAPPEN",
  "from_year": 2026,
  "timeframe": "unspecified future",
  "conv_level": "HIGH",
  "milestones": [
    {
      "kind": "llm_pre_event",
      "label": "AlphaFold 3 reaches general availability for academic and commercial structural biology",
      "notes": "Diamandis/Wissner-Gross cite AlphaFold 3 as the prototype for the broader 'flatten every discipline' thesis.",
      "source": "https://www.humanoidsdaily.com/news/the-shape-of-scale-new-figure-production-data-hints-at-exponential-ramp-up — directional precedent that AI is collapsing scientific timelines (AlphaFold 3 cited explicitly in prediction context as the canonical 'flattened overnight' example)",
      "status": "overdue",
      "weight": 0.4,
      "ordinal": -10,
      "source_id": null,
      "confidence": 0.85,
      "source_url": "https://deepmind.google/technologies/alphafold/alphafold-server/",
      "expected_date": "2026-01-31",
      "miss_emitted_at": "2026-05-02T22:07:21.384228+00:00",
      "miss_emitted_by": "metadata_milestone_sweep",
      "research_origin": "deep_research",
      "measurement_criterion": "DeepMind opens AlphaFold 3 for non-commercial server access and commercial licensing supporting protein-ligand and DNA/RNA complex prediction"
    },
    {
      "kind": "llm_pre_event",
      "label": "Anthropic ships multi-agent harness for long-horizon scientific work",
      "notes": "HIT — multi-agent harness shipped, supporting the 'generalist AI flattens disciplines' thesis on the tooling side.",
      "source": "https://www.anthropic.com/engineering/effective-harnesses-for-long-running-agents — Anthropic three-agent harness; InfoQ reporting April 2026",
      "status": "hit",
      "weight": 0.4,
      "ordinal": -9,
      "source_id": null,
      "confidence": 0.95,
      "source_url": "https://www.infoq.com/news/2026/04/anthropic-three-agent-harness-ai/",
      "expected_date": "2026-04-16",
      "observed_date": "2026-04-15",
      "research_origin": "deep_research",
      "measurement_criterion": "Anthropic publicly announces a three-agent (planner/generator/evaluator) harness or 'Managed Agents' product enabling multi-hour autonomous research/coding sessions"
    },
    {
      "kind": "prereq",
      "label": "Nvidia quadrupled chip production output while only doubling human headcount — achieved by deploying AI coding tools (Cursor, Claude Code) a",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -8,
      "source_id": "SEM_012",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Training runs costing $10 billion for a single model will commence sometime in 2025.",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -7,
      "source_id": "SEM_008",
      "expected_date": "2026-04-29",
      "observed_da
... (truncated)