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245_037predictionBiotech/LongevityAGI

Mosquito gene drive halted in Africa was possibly wrong to stop since mosquitoes are part of the food web (but invasives are not)

Predictor: Ben Lamm · ep#245 "AI + Synthetic Biology: The Most Transformative Technology in Human History | Ben Lamm (Colossal)" · source

Prior probability
45.0%
Current probability
37.5%
evolves via intake + LBP
Conviction
3/5
Signal quality
C
Resolution
pending
Window
2026-04-30 – 2040-09-30
Edges in / out
3 / 0
Tickers exposed
29

Prediction text

Mosquito gene drive halted in Africa was possibly wrong to stop since mosquitoes are part of the food web (but invasives are not) | people released gene drives in Africa around uh mosquitoes and everyone freaked out and then they stopped it... mosquitoes are a part of the food web. I don't think it was necessarily a bad idea to stop it because they were part of the food web, but we know invasive species are not a part of the food web

Watch events: ARC-AGI-2 scores; Frontier Math Tier 4 benchmark; SWE-bench Verified; Humanity's Last Exam

Verbatim quote

From episode "AI + Synthetic Biology: The Most Transformative Technology in Human History | Ben Lamm (Colossal)"
people released gene drives in Africa around uh mosquitoes and everyone freaked out and then they stopped it... mosquitoes are a part of the food web. I don't think it was necessarily a bad idea to stop it because they were part of the food web, but we know invasive species are not a part of the food web

Predictor: Ben Lamm

κ + Brier as of 2026-05-22
κ (discount)
0.688
Brier
0.0043
excellent
Hits / Misses
2 / 0
of 3 resolved
Hit rate
66.7%
Calibration plot (stated vs observed)

Evidence about this node from Ben Lamm is multiplied by κ in /api/intake. Lower κ = less weight; floors at 0.10 (effectively silenced) and caps at 1.00 (full weight).

Reference class

Not linked

This node isn't linked to a reference class. The Bayesian update applies without outside-view blending.

Probability over time

4 prob_history rows
0%25%50%75%100%prior 45%2026-04-302026-05-032026-05-10
intake v2milestone miss sweeplbp propagationreference class assignedlegacy v1prior_prob (analyst seed)current = 37.5%

Milestone chain

Pre-event signals (upstream prereqs + window checkpoints) → resolution event → downstream cascades. Status/dates update from linked nodes; re-derive nightly via scripts/ops/derive_milestones.py.
Leading chain: 2 fired ✓ · 6 pending
  1. 2025-08-22hitBurkina Faso suspends Target Malaria gene-drive trial (Aug 2025)
    How: Burkina Faso government announces formal halt of Target Malaria gene-drive trial
    Source: deep_research_enrichedconf 98%
  2. 2025-12-01hitTanzania-based gene-drive Anopheles trial publishes peer-reviewed efficacy
    How: Nature/Science peer-reviewed publication documenting gene-drive Anopheles inhibiting Plasmodium falciparum from patient samples
    Source: deep_research_enrichedconf 90%
  3. 2027-01-01 → 2029-12-31pendingSecond African nation re-permits gene-drive Anopheles trial
    How: Government of Uganda, Tanzania, or another African state issues regulatory authorization for an open-field gene-drive Anopheles release
    Source: llm_enrichedconf 50%
  4. 2028-09-09pendingQ1 window check-in (25%)
  5. 2027-01-01 → 2031-12-31pendingFirst gene-drive eradication targeting an invasive species achieves measurable population suppression
    How: Peer-reviewed paper or government report documents >=50% reduction in target invasive population in a defined geography via gene drive
    Source: llm_enrichedconf 40%
  6. 2028-01-01 → 2032-12-31pendingWHO/CBD adopts standardized gene-drive containment protocol distinguishing native vs invasive
    How: WHO Vector Control Advisory Group or Convention on Biological Diversity publishes formal guidance differentiating gene-drive use cases by ecological role
    Source: llm_enrichedconf 40%
  7. 2031-01-21pendingQ2 window check-in (50%)
  8. 2033-06-02pendingQ3 window check-in (75%)

No downstream cascades — this prediction is a leaf in the dependency graph.

What if this resolves?

Clamp this prediction TRUE or FALSE and run a counterfactual Gibbs sample. Surfaces the predictions whose marginals shift most under that assumption.
(live posterior: 37%)

Click a button to clamp this prediction and run a Gibbs sample. Returns the predictions whose marginals shift most. ~30s per run; ideal for stress-testing "if X resolves, what else moves?"

Evidence chain

Every probability update with full Bayesian provenance — chronological, latest first
LBP2026-05-10T02:00:02Z37.5%-1.3pp
Network propagation: 38.7% → 37.5%
6-iter LBP, residual 0.00584 · damping 0.5, w_intrinsic 0.5 · method lbp_v3 · run e5c18d29
LBP2026-05-03T02:00:01Z38.7%-2.6pp
Network propagation: 41.3% → 38.7%
6-iter LBP, residual 0.00677 · damping 0.5, w_intrinsic 0.5 · method lbp_v3 · run 1a683ac9
LBP2026-04-30T16:39:51Z41.3%-1.2pp
Network propagation: 42.6% → 41.3%
5-iter LBP, residual 0.00825 · damping 0.5, w_intrinsic 0.5 · method lbp_v2 · run 0c8a4ea3
LBP2026-04-30T02:18:57Z42.6%-2.4pp
Network propagation: 45.0% → 42.6%
5-iter LBP, residual 0.00825 · damping 0.5, w_intrinsic 0.5 · method lbp_v1 · run 592311ef

Network propagation neighbors

Top edges sorted by latest LBP cross-impact
All propagation →

Top incoming (parents)

Edges that influence THIS node's belief

KindNodeTheir probP(c|s=T)P(c|s=F)Δ implied
prereqS_ASI_SLOW_2040PLUS
ASI slow: post-2040 / soft takeoff
60.0%0.4500.050-0.085
killerTK03
AI Regulatory Moratorium (EU/US Capability Freeze)
10.0%0.0500.450+0.035
killerTK01
AGI Capability Plateau (2026-27 Training Stall)
15.0%0.0500.450+0.015

Top outgoing (children)

Predictions THIS node influences

No outgoing edges.

Ticker exposure

29 ticker(s) linked

Beneficiaries (21)

TWSTGTLBTXGCRSPILMNBBAISOUNDNANVDAPACBAIORCLSHOPTCEHYAMZNAZNGOOGLIBMBABAMETAMSFT

Adverse (7)

ACNCHGGCTSHFRSHIBMINFYPEGA

Prerequisites (3)

Predictions that must hit first
TypePredTitleDomainLag
prereqS_ASI_SLOW_2040PLUSASI slow: post-2040 / soft takeoffasi_recursive_self_improvement
killerTK01AGI Capability Plateau (2026-27 Training Stall)
killerTK03AI Regulatory Moratorium (EU/US Capability Freeze)

Dependents (0)

Predictions enabled by this
TypePredTitleDomainLag
No dependents

Raw metadata

From Thesis_Timeline_v1.0_FINAL workbook
{
  "nia": false,
  "url": "https://www.youtube.com/watch?v=Goa6c6Qz__I",
  "mode": "THESIS",
  "role": "Guest-CEO",
  "context": "people released gene drives in Africa around uh mosquitoes and everyone freaked out and then they stopped it... mosquitoes are a part of the food web. I don't think it was necessarily a bad idea to stop it because they were part of the food web, but we know invasive species are not a part of the food web",
  "verbatim": "people released gene drives in Africa around uh mosquitoes and everyone freaked out and then they stopped it... mosquitoes are a part of the food web. I don't think it was necessarily a bad idea to stop it because they were part of the food web, but we know invasive species are not a part of the food web",
  "conv_cues": "I don't think it was necessarily a bad idea",
  "direction": "HAPPEN",
  "timeframe": "Current",
  "conv_level": "MEDIUM",
  "milestones": [
    {
      "kind": "llm_pre_event",
      "label": "Burkina Faso suspends Target Malaria gene-drive trial (Aug 2025)",
      "source": "deep_research_enriched",
      "status": "hit",
      "weight": 0.4,
      "ordinal": -8,
      "source_id": null,
      "confidence": 0.98,
      "source_url": "https://countercurrents.org/2026/02/target-malaria-project-halted-in-burkina-faso-victory-for-opponents-of-open-field-gene-drive-releases/",
      "expected_date": "2025-08-22",
      "observed_date": "2025-08-22",
      "research_origin": "deep_research",
      "measurement_criterion": "Burkina Faso government announces formal halt of Target Malaria gene-drive trial"
    },
    {
      "kind": "llm_pre_event",
      "label": "Tanzania-based gene-drive Anopheles trial publishes peer-reviewed efficacy",
      "source": "deep_research_enriched",
      "status": "hit",
      "weight": 0.4,
      "ordinal": -7,
      "source_id": null,
      "confidence": 0.9,
      "source_url": "https://www.nature.com/articles/s41586-025-09685-6",
      "expected_date": "2026-02-14",
      "observed_date": "2025-12-01",
      "research_origin": "deep_research",
      "expected_date_range": {
        "to": "2026-06-30",
        "from": "2025-10-01"
      },
      "measurement_criterion": "Nature/Science peer-reviewed publication documenting gene-drive Anopheles inhibiting Plasmodium falciparum from patient samples"
    },
    {
      "kind": "llm_pre_event",
      "label": "Second African nation re-permits gene-drive Anopheles trial",
      "source": "llm_enriched",
      "status": "pending",
      "weight": 0.4,
      "ordinal": -6,
      "source_id": null,
      "confidence": 0.5,
      "expected_date": "2028-07-01",
      "research_origin": "training",
      "expected_date_range": {
        "to": "2029-12-31",
        "from": "2027-01-01"
      },
      "measurement_criterion": "Government of Uganda, Tanzania, or another African state issues regulatory authorization for an open-field gene-drive Anopheles release"
    },
    {
      "kind": "quartile_checkpoint",
      "label": "Q1 window check-in (25%)",
      "status": "pending",
      "weight": 0.05,
      "ordinal": -5,
      "source_id": null,
      "expected_date": "2028-09-09",
      "observed_date": null
    },
    {
      "kind": "llm_pre_event",
      "label": "First gene-drive eradication targeting an invasive species achieves measurable population suppression",
      "source": "llm_enriched",
      "status": "pending",
      "weight": 0.4,
      "ordinal": -4,
      "source_id": null,
      "confidence": 0.4,
      "expected_date": "2029-07-01",
      "research_origin": "training",
      "expected_date_range": {
        "to": "2031-12-31",
        "from": "2027-01-01"
      },
      "measurement_criterion": "Peer-reviewed paper or government report documents >=50% reduction in target invasive population in a defined geography via gene drive"
    },
    {
      "kind": "llm_post_event",
      "label": "WHO/CBD adopts standardized gene-drive containment protocol distinguishing native vs inv
... (truncated)