Colossal gene editing will reach thousands of edits (up from current hundreds)

Colossal gene editing will reach thousands of edits (up from current hundreds) | We're now doing hundreds of edits at a time... I think in the coming years that's thousands of edits, and those are those are not linear repeats, meaning they're all over the genome.

We're now doing hundreds of edits at a time... I think in the coming years that's thousands of edits, and those are those are not linear repeats, meaning they're all over the genome.

Beneficiaries (19)

Adverse (4)

{
  "nia": false,
  "qty": "From hundreds to thousands of edits simultaneously",
  "url": "https://www.youtube.com/watch?v=Goa6c6Qz__I",
  "mode": "FORECAST",
  "role": "Guest-CEO",
  "context": "We're now doing hundreds of edits at a time... I think in the coming years that's thousands of edits",
  "to_year": 2029,
  "verbatim": "We're now doing hundreds of edits at a time... I think in the coming years that's thousands of edits, and those are those are not linear repeats, meaning they're all over the genome.",
  "conv_cues": "I think in the coming years",
  "direction": "UP",
  "from_year": 2027,
  "timeframe": "Coming years (2027-2029)",
  "conv_level": "HIGH",
  "milestones": [
    {
      "kind": "llm_pre_event",
      "label": "Colossal Woolly Mouse: 8 simultaneous edits across 7 genes (already achieved)",
      "notes": "HIT — 8 edits in mice baseline. Lamm's 'hundreds' refers to elephant cell lines for mammoth project.",
      "source": "https://www.businesswire.com/news/home/20250304113074/en/Colossal-Creates-the-Colossal-Woolly-Mouse — Colossal Woolly Mouse, March 2025",
      "status": "hit",
      "weight": 0.4,
      "ordinal": -8,
      "source_id": null,
      "confidence": 0.99,
      "source_url": "https://www.businesswire.com/news/home/20250304113074/en/Colossal-Creates-the-Colossal-Woolly-Mouse-Showcasing-Breakthroughs-in-Multiplex-Genome-Editing-and-Trait-Engineering-on-the-Path-to-a-Mammoth",
      "expected_date": "2025-03-04",
      "observed_date": "2025-03-04",
      "research_origin": "deep_research",
      "measurement_criterion": "Colossal demonstrates 8 simultaneous gene edits across 7 genes in mice with peer-reviewed publication"
    },
    {
      "kind": "prereq",
      "label": "Colossal gene editing efficiency has risen from 15% industry / 40% internal to 90% at hundreds of edits",
      "status": "hit",
      "weight": 0.5,
      "ordinal": -7,
      "source_id": "245_025",
      "expected_date": "2026-04-29",
      "observed_date": "2026-04-29"
    },
    {
      "kind": "prereq",
      "label": "Colossal has major announcements coming this year with a local government on productionizing cloning of endangered species",
      "status": "pending",
      "weight": 0.5,
      "ordinal": -6,
      "source_id": "245_014",
      "expected_date": "2026-05-30",
      "observed_date": null
    },
    {
      "kind": "prereq",
      "label": "Longevity VC market expected to grow from $8.5B in 2024 to $12-18B in 2026.",
      "status": "pending",
      "weight": 0.5,
      "ordinal": -5,
      "source_id": "235_027",
      "expected_date": "2026-08-14",
      "observed_date": null
    },
    {
      "kind": "prereq",
      "label": "Colossal DNA synthesis delivery will reach 20x the largest prior delivery by end of 2026",
      "status": "pending",
      "weight": 0.5,
      "ordinal": -4,
      "source_id": "245_027",
      "expected_date": "2026-09-08",
      "observed_date": null
    },
    {
      "kind": "llm_pre_event",
      "label": "Mammoth-like elephant cell line crosses 100 simultaneous edits",
      "notes": "Lamm anchored 'hundreds' as current state — verification needed via published cell-line data.",
      "source": "Colossal Biosciences technical updates, Wikipedia/Contrary Research",
      "status": "pending",
      "weight": 0.4,
      "ordinal": -3,
      "source_id": null,
      "confidence": 0.55,
      "source_url": "https://en.wikipedia.org/wiki/Colossal_Biosciences",
      "expected_date": "2026-12-15",
      "research_origin": "deep_research",
      "expected_date_range": {
        "to": "2027-06-30",
        "from": "2026-06-01"
      },
      "measurement_criterion": "Colossal publishes data demonstrating ≥100 simultaneous edits in Asian elephant cell line for mammoth project"
    },
    {
      "kind": "llm_pre_event",
      "label": "Mammoth-like Asian elephant embryo produced",
      "notes": "Direct path-of-progress milestone for the gene-editing scaling claim.",
      "so
... (truncated)