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245_039predictionBiotech/Longevitysynbio

Colossal has not yet started work on dinosaurs, corals, dragons or Pokemon

Predictor: Ben Lamm · ep#245 "AI + Synthetic Biology: The Most Transformative Technology in Human History | Ben Lamm (Colossal)" · source

Prior probability
50.0%
Current probability
45.0%
evolves via intake + LBP
Conviction
4/5
Signal quality
C
Resolution
pending
Window
— – —
Edges in / out
1 / 0
Tickers exposed
24

Prediction text

Colossal has not yet started work on dinosaurs, corals, dragons or Pokemon | we aren't working on dragons and we're not working on Pokemon or corals yet

Verbatim quote

From episode "AI + Synthetic Biology: The Most Transformative Technology in Human History | Ben Lamm (Colossal)"
we aren't working on dragons and we're not working on Pokemon or corals yet

Predictor: Ben Lamm

κ + Brier as of 2026-05-22
κ (discount)
0.688
Brier
0.0043
excellent
Hits / Misses
2 / 0
of 3 resolved
Hit rate
66.7%
Calibration plot (stated vs observed)

Evidence about this node from Ben Lamm is multiplied by κ in /api/intake. Lower κ = less weight; floors at 0.10 (effectively silenced) and caps at 1.00 (full weight).

Reference class

Not linked

This node isn't linked to a reference class. The Bayesian update applies without outside-view blending.

Probability over time

2 prob_history rows
0%25%50%75%100%prior 50%2026-04-302026-04-30
intake v2milestone miss sweeplbp propagationreference class assignedlegacy v1prior_prob (analyst seed)current = 45.0%

Milestone chain

Pre-event signals (upstream prereqs + window checkpoints) → resolution event → downstream cascades. Status/dates update from linked nodes; re-derive nightly via scripts/ops/derive_milestones.py.
Leading chain: 1 fired ✓ · 2 pending
  1. 2026-04-30hitColossal announces fourth de-extinction species target (post-mammoth/dodo/thylacine)
    How: Colossal publicly announces fourth de-extinction target species beyond current mammoth/dodo/thylacine portfolio
    Source: Colossal press, https://www.axios.com/2026/04/30/colossal-biosciences-species-extinction-bluebuck — bluebuck announced 2026-04-30conf 99%
    Notes: HIT — Colossal added bluebuck on 2026-04-30 (yesterday relative to today's date). Still no dragons/Pokemon/dinos/corals — claim holds.
  2. 2026-05-01 → 2028-12-31pendingCoral-restoration GM/CRISPR program launched (would partially invalidate)
    How: Colossal announces coral-restoration / climate-resilient-coral program OR partners with coral-focused org (Reef Genomics, Australian Institute of Marine Science)
    Source: Colossal press, peer-reviewed publication, NOAA partner announcementsconf 30%
    Notes: Lamm explicitly excluded corals. Future inclusion would partially invalidate.
  3. 2026-05-01 → 2030-12-31pendingDinosaur de-extinction remains scientifically infeasible (no preserved DNA)
    How: No peer-reviewed publication demonstrates Mesozoic-era DNA recovery capable of supporting de-extinction (chickenosaurus / Jack Horner approach is morphological, not de-extinction)
    Source: Nature, Science, Cell — paleogenomics publicationsconf 95%
    Notes: DNA half-life ~521 years means dinosaur DNA fully degraded; physically impossible. Claim 'not working on dinosaurs' is structurally durable.

No downstream cascades — this prediction is a leaf in the dependency graph.

What if this resolves?

Clamp this prediction TRUE or FALSE and run a counterfactual Gibbs sample. Surfaces the predictions whose marginals shift most under that assumption.
(live posterior: 45%)

Click a button to clamp this prediction and run a Gibbs sample. Returns the predictions whose marginals shift most. ~30s per run; ideal for stress-testing "if X resolves, what else moves?"

Evidence chain

Every probability update with full Bayesian provenance — chronological, latest first
LBP2026-04-30T16:39:51Z45.0%-1.7pp
Network propagation: 46.7% → 45.0%
5-iter LBP, residual 0.00825 · damping 0.5, w_intrinsic 0.5 · method lbp_v2 · run 0c8a4ea3
LBP2026-04-30T02:18:57Z46.7%-3.3pp
Network propagation: 50.0% → 46.7%
5-iter LBP, residual 0.00825 · damping 0.5, w_intrinsic 0.5 · method lbp_v1 · run 592311ef

Network propagation neighbors

Top edges sorted by latest LBP cross-impact
All propagation →

Top incoming (parents)

Edges that influence THIS node's belief

KindNodeTheir probP(c|s=T)P(c|s=F)Δ implied
killerTK13
Biotech/Synbio Safety Event
15.0%0.0500.500-0.018

Top outgoing (children)

Predictions THIS node influences

No outgoing edges.

Ticker exposure

24 ticker(s) linked

Beneficiaries (19)

ABCLNTLASDGRPACBRXRXRLAYDNATXGTWSTABSICRSPILMNMDTABTAZNBNTXGEHCGOOGLSMMNY

Adverse (4)

NVOFMSDVAPFE

Prerequisites (1)

Predictions that must hit first
TypePredTitleDomainLag
killerTK13Biotech/Synbio Safety Event

Dependents (0)

Predictions enabled by this
TypePredTitleDomainLag
No dependents

Linked documents (2)

Auto-generated by cosine similarity from Polymarket / Manifold / EDGAR / GDELT
SimSourceTitleMarket probPolarityReviewedPublished
0.572github_releasemeta-llama/llama-models v0.2.0mentionspending2025-04-05
0.560github_releasemeta-llama/llama-cookbook v0.0.4.post1mentionspending2024-09-26

Raw metadata

From Thesis_Timeline_v1.0_FINAL workbook
{
  "nia": false,
  "url": "https://www.youtube.com/watch?v=Goa6c6Qz__I",
  "mode": "PREDICTION",
  "role": "Guest-CEO",
  "context": "we aren't working on dragons and we're not working on Pokemon or corals yet",
  "verbatim": "we aren't working on dragons and we're not working on Pokemon or corals yet",
  "conv_cues": "aren't working on; yet",
  "direction": "NOT_HAPPEN",
  "timeframe": "Current state / 'yet' implies future possibility",
  "conv_level": "HIGH",
  "milestones": [
    {
      "kind": "llm_pre_event",
      "label": "Colossal announces fourth de-extinction species target (post-mammoth/dodo/thylacine)",
      "notes": "HIT — Colossal added bluebuck on 2026-04-30 (yesterday relative to today's date). Still no dragons/Pokemon/dinos/corals — claim holds.",
      "source": "Colossal press, https://www.axios.com/2026/04/30/colossal-biosciences-species-extinction-bluebuck — bluebuck announced 2026-04-30",
      "status": "hit",
      "weight": 0.4,
      "ordinal": -3,
      "source_id": null,
      "confidence": 0.99,
      "source_url": "https://www.axios.com/2026/04/30/colossal-biosciences-species-extinction-bluebuck",
      "expected_date": "2027-03-01",
      "observed_date": "2026-04-30",
      "research_origin": "deep_research",
      "expected_date_range": {
        "to": "2027-12-31",
        "from": "2026-05-01"
      },
      "measurement_criterion": "Colossal publicly announces fourth de-extinction target species beyond current mammoth/dodo/thylacine portfolio"
    },
    {
      "kind": "llm_pre_event",
      "label": "Coral-restoration GM/CRISPR program launched (would partially invalidate)",
      "notes": "Lamm explicitly excluded corals. Future inclusion would partially invalidate.",
      "source": "Colossal press, peer-reviewed publication, NOAA partner announcements",
      "status": "pending",
      "weight": 0.4,
      "ordinal": -2,
      "source_id": null,
      "confidence": 0.3,
      "expected_date": "2027-08-31",
      "research_origin": "training",
      "expected_date_range": {
        "to": "2028-12-31",
        "from": "2026-05-01"
      },
      "measurement_criterion": "Colossal announces coral-restoration / climate-resilient-coral program OR partners with coral-focused org (Reef Genomics, Australian Institute of Marine Science)"
    },
    {
      "kind": "llm_pre_event",
      "label": "Dinosaur de-extinction remains scientifically infeasible (no preserved DNA)",
      "notes": "DNA half-life ~521 years means dinosaur DNA fully degraded; physically impossible. Claim 'not working on dinosaurs' is structurally durable.",
      "source": "Nature, Science, Cell — paleogenomics publications",
      "status": "pending",
      "weight": 0.4,
      "ordinal": -1,
      "source_id": null,
      "confidence": 0.95,
      "expected_date": "2028-08-30",
      "research_origin": "training",
      "expected_date_range": {
        "to": "2030-12-31",
        "from": "2026-05-01"
      },
      "measurement_criterion": "No peer-reviewed publication demonstrates Mesozoic-era DNA recovery capable of supporting de-extinction (chickenosaurus / Jack Horner approach is morphological, not de-extinction)"
    }
  ],
  "repeat_eps": 1,
  "sub_domain": "Longevity",
  "untimeable": true,
  "affiliation": "Colossal Biosciences",
  "attribution": "FIRST_PERSON",
  "episode_num": 245,
  "granularity": "VAGUE",
  "episode_date": "2026-04-07",
  "parse_method": "UNMAPPABLE",
  "domain_bucket": "Biotech",
  "episode_title": "AI + Synthetic Biology: The Most Transformative Technology in Human History | Ben Lamm (Colossal)",
  "flag_repeated": false,
  "in_5yr_window": false,
  "appears_in_eps": "245",
  "is_macro_claim": false,
  "total_mentions": 1,
  "priority_weight": 4,
  "ps_cluster_tags": [
    "C10"
  ],
  "active_end_month": 0,
  "recent_statement": "April 7 2026 Moonshots: Colossal gene editing 15%→40%→90% efficiency at hundreds of edits. UAE Biovault nine-figure partnership. Synbio market as large as AI (mu
... (truncated)